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  • Dehghan, M. (author)

Ultra-processed foods and mortality: analysis from the Prospective Urban and Rural Epidemiology study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier BV,2023

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  • LIBRIS-ID:oai:gup.ub.gu.se/327728
  • https://gup.ub.gu.se/publication/327728URI
  • https://doi.org/10.1016/j.ajcnut.2022.10.014DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Background: Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited. Objectives: We aimed to assess the association between consumption of UPFs and risk of mortality and major CVD in a cohort from multiple world regions. Design: This analysis includes 138,076 participants without a history of CVD between the ages of 35 and 70 y living on 5 continents, with a median follow-up of 10.2 y. We used country-specific validated food-frequency questionnaires to determine individuals' food intake. We classified foods and beverages based on the NOVA classification into UPFs. The primary outcome was total mortality (CV and non-CV mortality) and secondary outcomes were incident major cardiovascular events. We calculated hazard ratios using multivariable Cox frailty models and evaluated the association of UPFs with total mortality, CV mortality, non-CV mortality, and major CVD events. Results: In this study, 9227 deaths and 7934 major cardiovascular events were recorded during the follow-up period. We found a diet high in UPFs (>= 2 servings/d compared with 0 intake) was associated with higher risk of mortality (HR: 1.28; 95% CI: 1.15, 1.42; P-trend < 0.001), CV mortality (HR:1.17; 95% CI: 0.98, 1.41; P-trend = 0.04), and non-CV mortality (HR: 1.32; 95% CI 1.17, 1.50; P-trend < 0.001). We did not find a significant as-sociation between UPF intake and risk of major CVD. Conclusions: A diet with a high intake of UPFs was associated with a higher risk of mortality in a diverse multinational study. Globally, limiting the consumption of UPFs should be encouraged.

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  • Mente, A. (author)
  • Rangarajan, S. (author)
  • Mohan, V. (author)
  • Swaminathan, S. (author)
  • Avezum, A. (author)
  • Lear, S. A. (author)
  • Rosengren, Annika,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xrosan (author)
  • Poirier, P. (author)
  • Lanas, F. (author)
  • Lopez-Jaramillo, P. (author)
  • Soman, B. (author)
  • Wang, C. S. (author)
  • Orlandini, A. (author)
  • Mohammadifard, N. (author)
  • AlHabib, K. F. (author)
  • Chifamba, J. (author)
  • Yusufali, A. H. (author)
  • Iqbal, R. (author)
  • Khatib, R. (author)
  • Yeates, K. (author)
  • Puoane, T. (author)
  • Altuntas, Y. (author)
  • Co, H. U. (author)
  • Li, S. D. (author)
  • Liu, W. D. (author)
  • Zatonska, K. (author)
  • Yusuf, R. (author)
  • Ismail, N. (author)
  • Miller, V. (author)
  • Yusuf, S. (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: Elsevier BV117:1, s. 55-630002-9165

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