Search: onr:"swepub:oai:gup.ub.gu.se/327826" > Carpal Tunnel Syndr...
Fältnamn | Indikatorer | Metadata |
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000 | 04148naa a2200601 4500 | |
001 | oai:gup.ub.gu.se/327826 | |
003 | SwePub | |
008 | 240910s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3278262 URI |
024 | 7 | a https://doi.org/10.3390/biomedicines110617442 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fernandez-de-las-Penas, C.4 aut |
245 | 1 0 | a Carpal Tunnel Syndrome: Neuropathic Pain Associated or Not with a Nociplastic Condition |
264 | 1 | c 2023 |
520 | a Carpal tunnel syndrome (CTS) has been traditionally classified as primarily a neuropathic condition with or without pain. Precision medicine refers to an evidence-based method of grouping patients based on their susceptibility to biology, prognosis of a particular disease, or in their response to a specific treatment, and tailoring specific treatments accordingly. In 2021, the International Association for the Study of Pain (IASP) proposed a grading system for classifying patients into nociceptive, neuropathic, or nociplastic phenotypes. This position paper presents data supporting the possibility of subgrouping individuals with specific CTS related-pain into nociceptive, neuropathic, nociplastic or mixed-type phenotypes. Carpal tunnel syndrome is a neuropathic condition but can also be comorbid with a nociplastic pain condition. The presence of extra-median symptoms and the development of facilitated pain processing seem to be signs suggesting that specific CTS cases can be classified as the nociplastic pain phenotype. The clinical responses of therapeutic approaches for the management of CTS are inconclusive. Accordingly, the ability to identify the predominant pain phenotype in patients with CTS could likely be problematic for producing efficient treatment outcomes. In fact, the presence of a nociplastic or mixed-type pain phenotype would explain the lack of clinical effect of treatment interventions targeting the carpal tunnel area selectively. We propose a clinical decision tree by using the 2021 IASP classification criteria for identifying the predominant pain phenotype in people with CTS-related pain, albeit CTS being a priori a neuropathic pain condition. The identification of a nociplastic-associated condition requires a more nuanced multimodal treatment approach to achieve better treatment outcomes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
653 | a carpal tunnel syndrome | |
653 | a median nerve | |
653 | a nociceptive | |
653 | a neuropathic | |
653 | a nociplastic pain | |
653 | a precision medicine | |
653 | a peripheral drive | |
653 | a central | |
653 | a sensitization | |
653 | a sensitivity | |
653 | a symptoms | |
653 | a neuroplasticity | |
653 | a definition | |
653 | a prevalence | |
653 | a deficits | |
653 | a therapy | |
653 | a surgery | |
653 | a system | |
653 | a Biochemistry & Molecular Biology | |
653 | a Research & Experimental Medicine | |
653 | a Pharmacology & Pharmacy | |
700 | 1 | a Fuensalida-Novo, S.4 aut |
700 | 1 | a Nijs, Jou Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation4 aut |
700 | 1 | a Basson, A.4 aut |
700 | 1 | a Plaza-Manzano, G.4 aut |
700 | 1 | a Valera-Calero, J. A.4 aut |
700 | 1 | a Arendt-Nielsen, L.4 aut |
700 | 1 | a de-la-Llave-Rincon, A. I.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering4 org |
773 | 0 | t Biomedicinesg 11:6q 11:6x 2227-9059 |
856 | 4 8 | u https://gup.ub.gu.se/publication/327826 |
856 | 4 8 | u https://doi.org/10.3390/biomedicines11061744 |
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