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Plasma Galectin-4 L...
Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans
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- Jujic, Amra (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital
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- Vieira, João (author)
- Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine
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- Matuskova, Hana (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Experimental Medical Science,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Nilsson, Peter M (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Kardiovaskulär forskning - hypertoni,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital,North-West University
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- Lindblad, Ulf, 1950 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Olsen, M. H. (author)
- University of Southern Denmark
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- Duarte, Joao (author)
- Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Meissner, Anja (author)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vascular Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Augsburg,German Center for Neurodegenerative Diseases (DZNE), Bonn
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Magnusson, M. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: International Journal of Molecular Sciences. - 1661-6596 .- 1422-0067. ; 24:12
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Abstract
Subject headings
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- Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01-2.30; p = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- ischemic stroke
- cardiovascular disease
- diabetes
- obesity
- galectins
- peptide-1 receptor agonist
- cardiovascular outcomes
- type-2
- angiogenesis
- brain
- Biochemistry & Molecular Biology
- Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Jujic, Amra
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Vieira, João
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Matuskova, Hana
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Nilsson, Peter M
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Lindblad, Ulf, 1 ...
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Olsen, M. H.
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show more...
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Duarte, Joao
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Meissner, Anja
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Magnusson, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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Lund University