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Plasma Galectin-4 L...
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Jujic, AmraLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital
(author)
Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/328036
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https://gup.ub.gu.se/publication/328036URI
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https://doi.org/10.3390/ijms241210064DOI
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https://lup.lub.lu.se/record/8a6f58d8-3901-463b-95aa-dccbab7df5b8URI
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Subject category:art swepub-publicationtype
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Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01-2.30; p = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke.
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Vieira, JoãoLund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine(Swepub:lu)jo0416vi
(author)
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Matuskova, HanaLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Experimental Medical Science,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine,German Center for Neurodegenerative Diseases (DZNE), Bonn(Swepub:lu)ha1078ma
(author)
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Nilsson, Peter MLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Kardiovaskulär forskning - hypertoni,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital,North-West University(Swepub:lu)medf-mma
(author)
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Lindblad, Ulf,1950University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xliulf
(author)
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Olsen, M. H.University of Southern Denmark
(author)
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Duarte, JoaoLund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)jo2654du
(author)
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Meissner, AnjaLund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vascular Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Augsburg,German Center for Neurodegenerative Diseases (DZNE), Bonn(Swepub:lu)an0178me
(author)
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Magnusson, M.
(author)
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Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
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In:International Journal of Molecular Sciences24:121661-65961422-0067
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Jujic, Amra
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Vieira, João
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Matuskova, Hana
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Nilsson, Peter M
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Lindblad, Ulf, 1 ...
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Olsen, M. H.
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Duarte, Joao
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Meissner, Anja
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Magnusson, M.
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