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Sensitization patte...
Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander
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- Ermis, Özuygur, 1991 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.;Krefting Res Ctr, Med Regatan 1F Box 424, Gothenburg, Sweden.
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- Norouzi, Aram (author)
- Norvia Kliniken, Solna, Sweden.
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- Borres, Magnus P., 1956- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Thermo Fisher Sci, ImmunoDiagnost, Uppsala, Sweden.
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- Basna, Rani, 1981 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.
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- Ekerljung, Linda, 1979 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.
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- Malmhäll, Carina, 1959 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.
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- Goksör, Emma, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Queen Silv Childrens Hosp, Dept Pediat, Gothenburg, Sweden.
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- Wennergren, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Queen Silv Childrens Hosp, Dept Pediat, Gothenburg, Sweden.
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- Rådinger, Madeleine, 1967 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.
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- Lötvall, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.
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- Kankaanranta, Hannu, 1967 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.;Univ Tampere, Fac Med & Life Sci, Tampere, Finland.;Seinajoki Cent Hosp, Dept Resp Med, Seinajoki, Finland.
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- Nwaru, Bright I, 1978 (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Krefting Research Centre,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden.;Univ Gothenburg, Inst Med, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
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(creator_code:org_t)
- Wiley, 2023
- 2023
- English.
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In: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 13:8
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16-75years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Fel d 1
- allergic sensitization
- cat allergy
- lipocalins
- molecular allergens
- allergic sensitization
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ermis, Özuygur, ...
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Norouzi, Aram
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Borres, Magnus P ...
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Basna, Rani, 198 ...
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Ekerljung, Linda ...
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Malmhäll, Carina ...
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Goksör, Emma, 19 ...
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Wennergren, Göra ...
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Rådinger, Madele ...
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Lötvall, Jan, 19 ...
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Kankaanranta, Ha ...
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Nwaru, Bright I, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Respiratory Medi ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Clinical and tra ...
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University of Gothenburg
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Uppsala University