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Parental history of...
Parental history of dementia and the risk of dementia: A cross-sectional analysis of a global collaborative study
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Oh, D. J. (author)
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Bae, J. B. (author)
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Lipnicki, D. M. (author)
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Han, J. W. (author)
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Sachdev, P. S. (author)
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Kim, T. H. (author)
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Kwak, K. P. (author)
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Kim, B. J. (author)
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Kim, S. G. (author)
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Kim, J. L. (author)
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Moon, S. W. (author)
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Park, J. H. (author)
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Ryu, S. H. (author)
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Youn, J. C. (author)
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Lee, D. Y. (author)
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Lee, D. W. (author)
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Lee, S. B. (author)
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Lee, J. J. (author)
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Jhoo, J. H. (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Najar, Jenna, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Rydberg Sterner, Therese (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Guaita, A. (author)
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Vaccaro, R. (author)
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Rolandi, E. (author)
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Scarmeas, N. (author)
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Yannakoulia, M. (author)
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Kosmidis, M. H. (author)
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Riedel-Heller, S. G. (author)
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Roehr, S. (author)
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Dominguez, J. (author)
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De Guzman, M. F. (author)
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Fowler, K. C. (author)
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Lobo, A. (author)
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Saz, P. (author)
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Lopez-Anton, R. (author)
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Anstey, K. J. (author)
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Cherbuin, N. (author)
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Mortby, M. E. (author)
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Brodaty, H. (author)
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Trollor, J. (author)
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Kochan, N. (author)
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Kim, K. W. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Psychiatry and Clinical Neurosciences. - 1323-1316 .- 1440-1819. ; 77:8, s. 449-456
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring. Methods: For this cross-sectional study, we harmonized and pooled data for 17,194 older adults from nine population-based cohorts of eight countries. These studies conducted face-to-face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring. Results: The mean age of the participants was 72.8 +/- 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15-1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31-2.26), but not with the risk of non-AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15-1.97) and AD (OR = 1.80, 95% CI = 1.33-2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28-3.55 in males; OR = 1.68, 95% CI = 1.16-2.44 for females). Conclusions: Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- dementia
- maternal history
- parental history
- sex
- family-history
- alzheimers-disease
- normal individuals
- genetic-variation
- maternal history
- onset
- cohort
- age
- heritability
- prevalence
- Neurosciences & Neurology
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Oh, D. J.
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Bae, J. B.
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Lipnicki, D. M.
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Han, J. W.
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Sachdev, P. S.
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Kim, T. H.
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show more...
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Kwak, K. P.
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Kim, B. J.
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Kim, S. G.
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Kim, J. L.
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Moon, S. W.
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Park, J. H.
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Ryu, S. H.
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Youn, J. C.
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Lee, D. Y.
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Lee, D. W.
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Lee, S. B.
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Lee, J. J.
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Jhoo, J. H.
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Skoog, Ingmar, 1 ...
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Najar, Jenna, 19 ...
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Rydberg Sterner, ...
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Guaita, A.
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Vaccaro, R.
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Rolandi, E.
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Scarmeas, N.
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Yannakoulia, M.
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Kosmidis, M. H.
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Riedel-Heller, S ...
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Roehr, S.
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Dominguez, J.
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De Guzman, M. F.
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Fowler, K. C.
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Lobo, A.
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Saz, P.
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Lopez-Anton, R.
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Anstey, K. J.
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Cherbuin, N.
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Mortby, M. E.
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Brodaty, H.
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Trollor, J.
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Kochan, N.
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Kim, K. W.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Psychiatry and C ...
- By the university
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University of Gothenburg
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Karolinska Institutet