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The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications
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Cortese, S. (author)
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McGinn, K. (author)
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Hojlund, M. (author)
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Apter, A. (author)
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Arango, C. (author)
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Baeza, I. (author)
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Banaschewski, T. (author)
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Buitelaar, J. (author)
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Castro-Fornieles, J. (author)
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Coghill, D. (author)
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Cohen, D. (author)
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Grunblatt, E. (author)
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Hoekstra, P. J. (author)
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James, A. (author)
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Jeppesen, P. (author)
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Nagy, P. (author)
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Pagsberg, A. K. (author)
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Parellada, M. (author)
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Persico, A. M. (author)
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Purper-Ouakil, D. (author)
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Roessner, V. (author)
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Santosh, P. (author)
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Simonoff, E. (author)
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- Stevanovic, Dejan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Stringaris, A. (author)
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Vitiello, B. (author)
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Walitza, S. (author)
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Weizman, A. (author)
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Wohlfarth, T. (author)
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Wong, I. C. K. (author)
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Zalsman, G. (author)
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Zuddas, A. (author)
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Moreno, C. (author)
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Solmi, M. (author)
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Correll, C. U. (author)
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(creator_code:org_t)
- Elsevier BV, 2023
- English.
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In: Neuroscience and Biobehavioral Reviews. - : Elsevier BV. - 0149-7634. ; 149
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We aimed to identify promising novel medications for child and adolescent mental health problems. We systematically searched https://clinicaltrials.gov/ and https://www.clinicaltrialsregister.eu/ (from 01/01/ 2010-08/23/2022) for phase 2 or 3 randomized controlled trials (RCTs) of medications without regulatory approval in the US, Europe or Asia, including also RCTs of dietary interventions/probiotics. Additionally, we searched phase 4 RCTs of agents targeting unlicensed indications for children/adolescents with mental health disorders. We retrieved 234 ongoing or completed RCTs, including 26 (11%) with positive findings on & GE; 1 primary outcome, 43 (18%) with negative/unavailable results on every primary outcome, and 165 (70%) without publicly available statistical results. The only two compounds with evidence of significant effects that
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- efficacy
- disorders
- metaanalysis
- depression
- autism
- adhd
- Behavioral Sciences
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
To the university's database
- By the author/editor
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Cortese, S.
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McGinn, K.
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Hojlund, M.
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Apter, A.
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Arango, C.
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Baeza, I.
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show more...
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Banaschewski, T.
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Buitelaar, J.
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Castro-Fornieles ...
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Coghill, D.
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Cohen, D.
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Grunblatt, E.
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Hoekstra, P. J.
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James, A.
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Jeppesen, P.
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Nagy, P.
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Pagsberg, A. K.
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Parellada, M.
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Persico, A. M.
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Purper-Ouakil, D ...
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Roessner, V.
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Santosh, P.
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Simonoff, E.
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Stevanovic, Deja ...
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Stringaris, A.
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Vitiello, B.
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Walitza, S.
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Weizman, A.
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Wohlfarth, T.
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Wong, I. C. K.
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Zalsman, G.
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Zuddas, A.
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Moreno, C.
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Solmi, M.
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Correll, C. U.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuroscience and ...
- By the university
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University of Gothenburg