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Mediating role of a...
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Björnson, Elias,1988Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.
(author)
Mediating role of atherogenic lipoproteins in the relationship between liver fat and coronary artery calcification
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/328508
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https://gup.ub.gu.se/publication/328508URI
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https://doi.org/10.1038/s41598-023-39390-1DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511149URI
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Non-alcoholic fatty liver disease (NAFLD) is associated with increased secretion of apoB-containing lipoproteins and increased risk of coronary heart disease (CHD). ApoB-containing lipoproteins include low-density lipoproteins (LDLs) and triglyceride-rich lipoproteins (TRLs); and since both LDLs and TRLs are causally related to CHD, they may mediate a portion of the increased risk of atherosclerosis seen in people with NAFLD. In a cohort of 4161 middle aged men and women, we performed mediation analysis in order to quantify the mediating effect of apoB-containing lipoproteins in the relationship between liver fat and atherosclerosis-as measured by coronary artery calcium score (CACS). We found plasma apoB to mediate 17.6% (95% CI 11-24) of the association between liver fat and CACS. Plasma triglycerides and TRL-cholesterol (both proximate measures of TRL particles) mediated 22.3% (95% CI 11-34) and 21.6% (95% CI 10-33) of the association respectively; whereas LDL-cholesterol mediated 5.4% (95% CI 2.0-9.4). In multivariable models, the mediating effect of TRL-cholesterol and plasma triglycerides showed, again, a higher degree of mediation than LDL-cholesterol, corroborating the results seen in the univariable models. In summary, we find around 20% of the association between liver fat and CACS to be mediated by apoB-containing lipoproteins. In addition, we find that TRLs mediate the majority of this effect whereas LDLs mediate a smaller effect. These results explain part of the observed CAD-risk burden for people with NAFLD and further suggest that TRL-lowering may be particularly beneficial to mitigate NAFLD-associated coronary artery disease risk.
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Samaras, DimitriosGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.
(author)
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Adiels, Martin,1976Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Wallenberg Laboratory,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Gothenburg, Sweden.(Swepub:gu)xadima
(author)
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Kullberg, Joel,1979-Uppsala universitet,Radiologi,Antaros Med, S-43183 Mölndal, Sweden.(Swepub:uu)jokul377
(author)
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Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Physiol, Reg Vastra Gotaland, S-41345 Gothenburg, Sweden.(Swepub:gu)xbafre
(author)
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Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Physiol, Reg Vastra Gotaland, S-41345 Gothenburg, Sweden.(Swepub:gu)xbgort
(author)
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Gummesson, Anders,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Genet, Reg Vastra Gotaland, S-41345 Gothenburg, Sweden.(Swepub:gu)xguman
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Göteborgs universitetWallenberglaboratoriet
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In:Scientific Reports: Springer Nature13:12045-2322
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