Search: onr:"swepub:oai:gup.ub.gu.se/328577" >
Recanalization Ther...
Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration
-
Traenka, C. (author)
-
Lorscheider, J. (author)
-
Hametner, C. (author)
-
show more...
-
Baumgartner, P. (author)
-
Gralla, J. (author)
-
Magoni, M. (author)
-
Martinez-Majander, N. (author)
-
Casolla, B. (author)
-
Feil, K. (author)
-
Pascarella, R. (author)
-
Papanagiotou, P. (author)
-
- Nordanstig, Annika, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
Padjen, V. (author)
-
Cereda, C. W. (author)
-
Psychogios, M. (author)
-
Nolte, C. H. (author)
-
Zini, A. (author)
-
Michel, P. (author)
-
Bejot, Y. (author)
-
Kastrup, A. (author)
-
Zedde, M. (author)
-
Kagi, G. (author)
-
Kellert, L. (author)
-
Henon, H. (author)
-
Curtze, S. (author)
-
Pezzini, A. (author)
-
Arnold, M. (author)
-
Wegener, S. (author)
-
Ringleb, P. (author)
-
Tatlisumak, T. (author)
-
Nederkoorn, P. J. (author)
-
Engelter, S. T. (author)
-
Gensickle, H. (author)
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Journal of Stroke. - 2287-6391. ; 25:2
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.5...
-
show less...
Abstract
Subject headings
Close
- Background and Purpose This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD).Methods This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015-2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0-2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching.Results Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10-19] vs. 4 [2-7], P<0.001). The frequency of favorable 3-month outcome did not differ significantly between both groups (EVT: 64.0% vs. IVT: 86.8%; ORadjusted 0.56 [0.24-1.32]). EVT was associated with higher rates of recanalization (80.5% vs. 40.7%; ORadjusted 8.85 [4.28-18.29]) compared to IVT. All secondary analyses showed higher recanalization rates in the EVT-group, which however never translated into better functional outcome rates compared to the IVT-group.Conclusion We observed no signal of superiority of EVT over IVT regarding functional outcome in CeAD-patients with AIS and LVO despite higher rates of complete recanalization with EVT. Whether pathophysiological CeAD-characteristics or their younger age might explain this observation deserves further research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cervical artery dissection
- Stroke
- Endovascular treatment
- Thrombolysis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Traenka, C.
-
Lorscheider, J.
-
Hametner, C.
-
Baumgartner, P.
-
Gralla, J.
-
Magoni, M.
-
show more...
-
Martinez-Majande ...
-
Casolla, B.
-
Feil, K.
-
Pascarella, R.
-
Papanagiotou, P.
-
Nordanstig, Anni ...
-
Padjen, V.
-
Cereda, C. W.
-
Psychogios, M.
-
Nolte, C. H.
-
Zini, A.
-
Michel, P.
-
Bejot, Y.
-
Kastrup, A.
-
Zedde, M.
-
Kagi, G.
-
Kellert, L.
-
Henon, H.
-
Curtze, S.
-
Pezzini, A.
-
Arnold, M.
-
Wegener, S.
-
Ringleb, P.
-
Tatlisumak, T.
-
Nederkoorn, P. J ...
-
Engelter, S. T.
-
Gensickle, H.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Journal of Strok ...
- By the university
-
University of Gothenburg