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Diabetes status and...
Diabetes status and other factors as correlates of risk for thrombotic and thromboembolic events during SARS-CoV-2 infection: A nationwide retrospective case-control study using Cerner Real-World Data & TRADE
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Tallon, E. M. (author)
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Gallagher, M. P. (author)
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Staggs, V. S. (author)
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Ferro, D. (author)
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Murthy, D. B. (author)
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Ebekozien, O. (author)
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Kosiborod, M. N. (author)
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- Lind, Marcus, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Manrique-Acevedo, C. (author)
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Shyu, C. R. (author)
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Clements, M. A. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Bmj Open. - 2044-6055. ; 13:7
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https://doi.org/10.1...
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Abstract
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- ObjectivesWe sought to examine in individuals with SARS-CoV-2 infection whether risk for thrombotic and thromboembolic events (TTE) is modified by presence of a diabetes diagnosis. Furthermore, we analysed whether differential risk for TTEs exists in type 1 diabetes mellitus (T1DM) versus type 2 diabetes mellitus (T2DM). DesignRetrospective case-control study. SettingThe December 2020 version of the Cerner Real-World Data COVID-19 database is a deidentified, nationwide database containing electronic medical record (EMR) data from 87 US-based health systems. ParticipantsWe analysed EMR data for 322 482 patients >17 years old with suspected or confirmed SARS-CoV-2 infection who received care between December 2019 and mid-September 2020. Of these, 2750 had T1DM; 57 811 had T2DM; and 261 921 did not have diabetes. OutcomeTTE, defined as presence of a diagnosis code for myocardial infarction, thrombotic stroke, pulmonary embolism, deep vein thrombosis or other TTE. ResultsOdds of TTE were substantially higher in patients with T1DM (adjusted OR (AOR) 2.23 (1.93-2.59)) and T2DM (AOR 1.52 (1.46-1.58)) versus no diabetes. Among patients with diabetes, odds of TTE were lower in T2DM versus T1DM (AOR 0.84 (0.72-0.98)). ConclusionsRisk of TTE during COVID-19 illness is substantially higher in patients with diabetes. Further, risk for TTEs is higher in those with T1DM versus T2DM. Confirmation of increased diabetes-associated clotting risk in future studies may warrant incorporation of diabetes status into SARS-CoV-2 infection treatment algorithms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- COVID-19
- DIABETES & ENDOCRINOLOGY
- Thromboembolism
- Stroke
- Health informatics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bmj Open
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- By the author/editor
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Tallon, E. M.
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Gallagher, M. P.
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Staggs, V. S.
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Ferro, D.
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Murthy, D. B.
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Ebekozien, O.
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show more...
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Kosiborod, M. N.
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Lind, Marcus, 19 ...
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Manrique-Acevedo ...
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Shyu, C. R.
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Clements, M. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Bmj Open
- By the university
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University of Gothenburg