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Variation in respon...
Variation in response rates to isolated limb perfusion in different soft-tissue tumour subtypes: an international multi-centre study
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Reijers, S. J. M. (author)
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Davies, E. (author)
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Gruenhagen, D. J. (author)
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Fiore, M. (author)
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Honore, C. (author)
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Rastrelli, M. (author)
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Vassos, N. (author)
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Podleska, L. E. (author)
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Niethard, M. (author)
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Jakob, J. (author)
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Perhavec, A. (author)
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Duarte, C. (author)
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Gonzalez, F. (author)
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Deroose, J. P. (author)
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Stas, M. (author)
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Boecxstaens, V. (author)
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Schrage, Y. (author)
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Snow, H. (author)
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Algarra, S. M. (author)
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Said, H. M. (author)
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Garcia-Ortega, D. Y. (author)
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Martin, K. (author)
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- Mattsson, Jan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Djafarrian, R. (author)
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Di Lorenzo, G. (author)
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Colombo, C. (author)
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Gronchi, A. (author)
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Matter, M. (author)
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Verhoef, C. (author)
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- Olofsson Bagge, Roger, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Hohenberger, P. (author)
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Hayes, A. J. (author)
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Houdt, W. J. V. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: European Journal of Cancer. - 0959-8049. ; 190
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https://doi.org/10.1...
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Abstract
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- Objective: The aim of this study was to investigate the response rates of different extremity soft-tissue sarcoma subtypes (eSTS) after isolated limb perfusion (ILP), based on an international multi-centre study. Materials and methods: The retrospective cohort comprised eSTS patients from 17 specialised ILP centres that underwent melphalan-based ILP, with or without recombinant human tumour necrosis factor (rhTNF & alpha;) (TM-ILP and M-ILP, respectively). Response was measured on imaging (magnetic resonance imaging) and/or clinical response, for which M-ILPs were excluded. Results: A total of 1109 eSTS patients were included. The three most common histological subtypes were undifferentiated pleomorphic sarcoma (17%, n = 184), synovial sarcoma (16%, n = 175) and myxofibrosarcoma (8%, n = 87). rhTNF & alpha; was used in 93% (TM-ILP) and resulted in a significantly better overall response rate (ORR, p = 0.031) and complete responses (CR, p < 0.001) in comparison to M-ILP, without significant differences among histological subgroups. The ORR of TM-ILP was 68%, including 17% CR. Also, 80% showed progressive disease. Significantly higher response rates were shown for Kaposi sarcoma (KS) with 42% CR and 96% ORR (both p < 0.001), and significantly higher CR rates for angiosarcoma (AS, 45%, p < 0.001) and clear cell sarcoma (CCS, 31%, p = 0.049). ILP was followed by resection & LE; 6 months in 80% of the patients. The overall limb salvage rate was 88%, without significant differences among histological subgroups, but was significantly higher for ILP responders compared to non-responders (93% versus 76%, p < 0.001). Conclusion: ILP resulted in high response and LRS among all eSTS subtypes, however, with significant differences between subtypes with most promising results for KS, AS and CCS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Soft-tissue sarcoma
- Response evaluation
- Isolated limb perfusion
- ILP
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Reijers, S. J. M ...
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Davies, E.
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Gruenhagen, D. J ...
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Fiore, M.
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Honore, C.
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Rastrelli, M.
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show more...
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Vassos, N.
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Podleska, L. E.
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Niethard, M.
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Jakob, J.
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Perhavec, A.
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Duarte, C.
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Gonzalez, F.
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Deroose, J. P.
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Stas, M.
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Boecxstaens, V.
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Schrage, Y.
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Snow, H.
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Algarra, S. M.
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Said, H. M.
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Garcia-Ortega, D ...
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Martin, K.
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Mattsson, Jan
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Djafarrian, R.
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Di Lorenzo, G.
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Colombo, C.
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Gronchi, A.
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Matter, M.
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Verhoef, C.
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Olofsson Bagge, ...
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Hohenberger, P.
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Hayes, A. J.
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Houdt, W. J. V.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
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University of Gothenburg