Search: onr:"swepub:oai:gup.ub.gu.se/329192" >
Recurrent Events in...
Recurrent Events in Cardiovascular Trials: JACC State-of-the-Art Review.
-
Gregson, John (author)
-
Stone, Gregg W (author)
-
Bhatt, Deepak L (author)
-
show more...
-
Packer, Milton (author)
-
Anker, Stefan D (author)
-
Zeller, Cordula (author)
-
- Redfors, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Pocock, Stuart J (author)
-
show less...
-
(creator_code:org_t)
-
-
show more...
-
-
show less...
- 2023
- 2023
- English.
-
In: Journal of the American College of Cardiology. - 1558-3597. ; 82:14, s. 1445-1463
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Many randomized trials in cardiovascular disease have repeat nonfatal events (such as hospitalizations) occurring during patient follow-up; yet, it remains common practice to have time-to-first event as the primary outcome. We explore the value of analyses that include repeat events. Do they help us understand the effect of treatment and total disease burden? Do they enhance statistical power? Should they become a trial's primary analysis? It may also be difficult to choose which of the various statistical methods for analyzing repeat events to use, and we provide a nontechnical guide to what each method is doing. We compare several methods for repeat events: Lin Wei Yang Ying, negative binomial, joint frailty, win ratio, and area under the curve. We illustrate their performance in 5 large cardiovascular trials and compare them with time-to-first-event analyses. We review their use in recently published heart failure trials and make recommendations for their use in future trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database