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Recurrent Events in...
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Gregson, John
(författare)
Recurrent Events in Cardiovascular Trials: JACC State-of-the-Art Review.
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/329192
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https://gup.ub.gu.se/publication/329192URI
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https://doi.org/10.1016/j.jacc.2023.07.024DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Many randomized trials in cardiovascular disease have repeat nonfatal events (such as hospitalizations) occurring during patient follow-up; yet, it remains common practice to have time-to-first event as the primary outcome. We explore the value of analyses that include repeat events. Do they help us understand the effect of treatment and total disease burden? Do they enhance statistical power? Should they become a trial's primary analysis? It may also be difficult to choose which of the various statistical methods for analyzing repeat events to use, and we provide a nontechnical guide to what each method is doing. We compare several methods for repeat events: Lin Wei Yang Ying, negative binomial, joint frailty, win ratio, and area under the curve. We illustrate their performance in 5 large cardiovascular trials and compare them with time-to-first-event analyses. We review their use in recently published heart failure trials and make recommendations for their use in future trials.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Stone, Gregg W
(författare)
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Bhatt, Deepak L
(författare)
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Packer, Milton
(författare)
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Anker, Stefan D
(författare)
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Zeller, Cordula
(författare)
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Redfors, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xredbj
(författare)
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Pocock, Stuart J
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
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Göteborgs universitet
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Gothenburg University
Sammanhörande titlar
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Ingår i:Journal of the American College of Cardiology82:14, s. 1445-14631558-3597
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