Search: onr:"swepub:oai:gup.ub.gu.se/329201" > Outcomes in Patient...
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000 | 04744naa a2200541 4500 | |
001 | oai:gup.ub.gu.se/329201 | |
003 | SwePub | |
008 | 240910s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3292012 URI |
024 | 7 | a https://doi.org/10.1001/jamaneurol.2023.32402 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Misra, Shubham4 aut |
245 | 1 0 | a Outcomes in Patients With Poststroke Seizures: A Systematic Review and Meta-Analysis. |
264 | 1 | c 2023 |
520 | a Published data about the impact of poststroke seizures (PSSs) on the outcomes of patients with stroke are inconsistent and have not been systematically evaluated, to the authors' knowledge.To investigate outcomes in people with PSS compared with people without PSS.MEDLINE, Embase, PsycInfo, Cochrane, LILACS, LIPECS, and Web of Science, with years searched from 1951 to January 30, 2023.Observational studies that reported PSS outcomes.The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was used for abstracting data, and the Joanna Briggs Institute tool was used for risk-of-bias assessment. Data were reported as odds ratio (OR) and standardized mean difference (SMD) with a 95% CI using a random-effects meta-analysis. Publication bias was assessed using funnel plots and the Egger test. Outlier and meta-regression analyses were performed to explore the source of heterogeneity. Data were analyzed from November 2022 to January 2023.Measured outcomes were mortality, poor functional outcome (modified Rankin scale [mRS] score 3-6), disability (mean mRS score), recurrent stroke, and dementia at patient follow-up.The search yielded 71 eligible articles, including20110 patients with PSS and 1166085 patients without PSS. Of the participants with PSS, 1967 (9.8%) had early seizures, and 10605 (52.7%) had late seizures. The risk of bias was high in 5 studies (7.0%), moderate in 35 (49.3%), and low in 31 (43.7%). PSSs were associated with mortality risk (OR, 2.1; 95% CI, 1.8-2.4), poor functional outcome (OR, 2.2; 95% CI, 1.8-2.8), greater disability (SMD, 0.6; 95% CI, 0.4-0.7), and increased dementia risk (OR, 3.1; 95% CI, 1.3-7.7) compared with patients without PSS. In subgroup analyses, early seizures but not late seizures were associated with mortality (OR, 2.4; 95% CI, 1.9-2.9 vs OR, 1.2; 95% CI, 0.8-2.0) and both ischemic and hemorrhagic stroke subtypes were associated with mortality (OR, 2.2; 95% CI, 1.8-2.7 vs OR, 1.4; 95% CI, 1.0-1.8). In addition, early and late seizures (OR, 2.4; 95% CI, 1.6-3.4 vs OR, 2.7; 95% CI, 1.8-4.1) and stroke subtypes were associated with poor outcomes (OR, 2.6; 95% CI, 1.9-3.7 vs OR, 1.9; 95% CI, 1.0-3.6).Results of this systematic review and meta-analysis suggest that PSSs were associated with significantly increased mortality and severe disability in patients with history of stroke. Unraveling these associations is a high clinical and research priority. Trials of interventions to prevent seizures may be warranted. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Kasner, Scott E4 aut |
700 | 1 | a Dawson, Jesse4 aut |
700 | 1 | a Tanaka, Tomotaka4 aut |
700 | 1 | a Zhao, Yize4 aut |
700 | 1 | a Zaveri, Hitten P4 aut |
700 | 1 | a Eldem, Ece4 aut |
700 | 1 | a Vazquez, Juan4 aut |
700 | 1 | a Silva, Lucas Scárdua4 aut |
700 | 1 | a Mohidat, Saba4 aut |
700 | 1 | a Hickman, L Brian4 aut |
700 | 1 | a Khan, Erum I4 aut |
700 | 1 | a Funaro, Melissa C4 aut |
700 | 1 | a Nicolo, John-Paul4 aut |
700 | 1 | a Mazumder, Rajarshi4 aut |
700 | 1 | a Yasuda, Clarissa Lin4 aut |
700 | 1 | a Stibrant Sunnerhagen, Katharina,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xstika |
700 | 1 | a Ihara, Masafumi4 aut |
700 | 1 | a Ross, Joseph S4 aut |
700 | 1 | a Liebeskind, David S4 aut |
700 | 1 | a Kwan, Patrick4 aut |
700 | 1 | a Quinn, Terence J4 aut |
700 | 1 | a Engel, Jerome4 aut |
700 | 1 | a Mishra, Nishant K4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap4 org |
773 | 0 | t JAMA neurologyg 80:11, s. 1155-1165q 80:11<1155-1165x 2168-6149x 2168-6157 |
856 | 4 8 | u https://gup.ub.gu.se/publication/329201 |
856 | 4 8 | u https://doi.org/10.1001/jamaneurol.2023.3240 |
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