Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.

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Beaumont, Robin NUniversity of Exeter (author)

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.

Article/chapterEnglish2023

Publisher, publication year, extent ...

2023

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LIBRIS-ID:oai:gup.ub.gu.se/329398
https://gup.ub.gu.se/publication/329398URI
https://doi.org/10.1038/s41588-023-01520-wDOI
https://lup.lub.lu.se/record/8987bd1e-b0f3-4e7b-9663-74ee79f05987URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n=65,405), maternal (n=61,228) and paternal (n=52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
amino acid
antibody
potassium channel KCNQ1
adult
amino acid transport
Article
birth weight
controlled study
female
fetus
fetus growth
gene locus
genetic correlation
genome
genome-wide association study
genotype
gestational age
human
major clinical study
male
Mendelian randomization analysis
morphology
placenta
placenta development
placenta weight
preeclampsia
pregnancy
pregnancy complication
progeny

Added entries (persons, corporate bodies, meetings, titles ...)

Flatley, Christopher (author)
Vaudel, Marc (author)
Wu, Xiaoping (author)
Chen, Jing (author)
Moen, Gunn-Helen (author)
Skotte, Line (author)
Helgeland, Øyvind (author)
Solé-Navais, Pol (author)
Banasik, Karina (author)
Albiñana, Clara (author)
Ronkainen, Justiina (author)
Fadista, J.Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-jft (author)
Stinson, Sara Elizabeth (author)
Trajanoska, Katerina (author)
Wang, Carol A (author)
Westergaard, David (author)
Srinivasan, Sundararajan (author)
Sánchez-Soriano, Carlos (author)
Bilbao, Jose Ramon (author)
Allard, Catherine (author)
Groleau, Marika (author)
Kuulasmaa, Teemu (author)
Leirer, Daniel J (author)
White, Frédérique (author)
Jacques, Pierre-Étienne (author)
Cheng, Haoxiang (author)
Hao, Ke (author)
Andreassen, Ole A (author)
Åsvold, Bjørn Olav (author)
Atalay, Mustafa (author)
Bhatta, Laxmi (author)
Bouchard, Luigi (author)
Brumpton, Ben Michael (author)
Brunak, Søren (author)
Bybjerg-Grauholm, Jonas (author)
Ebbing, Cathrine (author)
Elliott, Paul (author)
Engelbrechtsen, Line (author)
Erikstrup, Christian (author)
Estarlich, Marisa (author)
Franks, Stephen (author)
Gaillard, Romy (author)
Geller, Frank (author)
Grove, Jakob (author)
Hougaard, David M (author)
Kajantie, Eero (author)
Morgen, Camilla S (author)
Nohr, Ellen A (author)
Nyegaard, Mette (author)
Palmer, Colin N A (author)
Pedersen, Ole Birger (author)
Rivadeneira, Fernando (author)
Sebert, Sylvain (author)
Shields, Beverley M (author)
Stoltenberg, Camilla (author)
Surakka, Ida (author)
Thørner, Lise Wegner (author)
Ullum, Henrik (author)
Vaarasmaki, Marja (author)
Vilhjalmsson, Bjarni J (author)
Willer, Cristen J (author)
Lakka, Timo A (author)
Gybel-Brask, Dorte (author)
Bustamante, Mariona (author)
Hansen, Torben (author)
Pearson, Ewan R (author)
Reynolds, Rebecca M (author)
Ostrowski, Sisse R (author)
Pennell, Craig E (author)
Jaddoe, Vincent W V (author)
Felix, Janine F (author)
Hattersley, Andrew T (author)
Melbye, Mads (author)
Lawlor, Deborah A (author)
Hveem, Kristian (author)
Werge, Thomas (author)
Nielsen, Henriette Svarre (author)
Magnus, Per (author)
Evans, David M (author)
Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo (author)
Järvelin, Marjo-Riitta (author)
Zhang, Ge (author)
Hivert, Marie-France (author)
Johansson, Stefan (author)
Freathy, Rachel M (author)
Feenstra, BjarkeCopenhagen University Hospital (author)
Njølstad, Pål RUniversity of Bergen (author)
University of ExeterTranslationell muskelforskning (creator_code:org_t)
et al.

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In:Nature genetics55:11, s. 1807-191546-17181061-4036

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By the author/editor: Beaumont, Robin ...; Flatley, Christo ...; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen; show more...; Skotte, Line; Helgeland, Øyvin ...; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justi ...; Fadista, J.; Stinson, Sara El ...; Trajanoska, Kate ...; Wang, Carol A; Westergaard, Dav ...; Srinivasan, Sund ...; Sánchez-Soriano, ...; Bilbao, Jose Ram ...; Allard, Catherin ...; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J; White, Frédériqu ...; Jacques, Pierre- ...; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole ...; Åsvold, Bjørn Ol ...; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Mi ...; Brunak, Søren; Bybjerg-Grauholm ...; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, ...; Erikstrup, Chris ...; Estarlich, Maris ...; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David ...; Kajantie, Eero; Morgen, Camilla ...; Nohr, Ellen A; Nyegaard, Mette; Palmer, Colin N ...; Pedersen, Ole Bi ...; Rivadeneira, Fer ...; Sebert, Sylvain; Shields, Beverle ...; Stoltenberg, Cam ...; Surakka, Ida; Thørner, Lise We ...; Ullum, Henrik; Vaarasmaki, Marj ...; Vilhjalmsson, Bj ...; Willer, Cristen ...; Lakka, Timo A; Gybel-Brask, Dor ...; Bustamante, Mari ...; Hansen, Torben; Pearson, Ewan R; Reynolds, Rebecc ...; Ostrowski, Sisse ...; Pennell, Craig E; Jaddoe, Vincent ...; Felix, Janine F; Hattersley, Andr ...; Melbye, Mads; Lawlor, Deborah ...; Hveem, Kristian; Werge, Thomas; Nielsen, Henriet ...; Magnus, Per; Evans, David M; Jacobsson, Bo, 1 ...; Järvelin, Marjo- ...; Zhang, Ge; Hivert, Marie-Fr ...; Johansson, Stefa ...; Freathy, Rachel ...; Feenstra, Bjarke; Njølstad, Pål R; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Nature genetics

By the university: University of Gothenburg; Lund University

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