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Evidence of a causa...
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-02-01
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Springer Science and Business Media LLC,2023
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/329974
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https://gup.ub.gu.se/publication/329974URI
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https://doi.org/10.1038/s41467-023-35974-7DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153370600URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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Tyrmi, J. S.
(author)
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Rahmioglu, N.
(author)
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Zondervan, K. T.
(author)
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Becker, C. M.
(author)
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Uimari, O.
(author)
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Kettunen, J.
(author)
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Palotie, A.
(author)
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Daly, M.
(author)
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Riley-Gills, B.
(author)
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Jacob, H.
(author)
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Paul, D.
(author)
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Matakidou, A.
(author)
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Platt, A.
(author)
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Runz, H.
(author)
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John, S.
(author)
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Okafo, G.
(author)
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Lawless, N.
(author)
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Salminen-Mankonen, H.
(author)
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Plenge, R.
(author)
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Maranville, J.
(author)
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McCarthy, M.
(author)
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Ehm, M. G.
(author)
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Auro, K.
(author)
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Longerich, S.
(author)
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Fox, C.
(author)
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Malarstig, A.
(author)
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Klinger, K.
(author)
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Chatelain, C.
(author)
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Gossel, M.
(author)
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Estrada, K.
(author)
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Graham, R.
(author)
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Yang, R.
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O'Donnell, C.
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Makela, T. P.
(author)
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Kaprio, J.
(author)
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Virolainen, P.
(author)
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Hakanen, A.
(author)
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Kilpi, T.
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Perola, M.
(author)
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Partanen, J.
(author)
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Pitkaranta, A.
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Raivio, T.
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Serpi, R.
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Laitinen, T.
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Kosma, V. M.
(author)
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Laukkanen, J.
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Hautalahti, M.
(author)
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Tuovila, O.
(author)
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Pakkanen, R.
(author)
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Waring, J.
(author)
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Riley-Gillis, B.
(author)
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Rahimov, F.
(author)
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Tachmazidou, I.
(author)
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Chen, C. Y.
(author)
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Ding, Z. H.
(author)
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Jung, M.
(author)
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Biswas, S.
(author)
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Pendergrass, R.
(author)
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Pulford, D.
(author)
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Raghavan, N.
(author)
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Huertas-Vazquez, A.
(author)
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Sul, J. H.
(author)
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Hu, X. L.
(author)
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Hedman, A.
(author)
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Rivas, M.
(author)
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Waterworth, D.
(author)
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Renaud, N.
(author)
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Obeidat, M.
(author)
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Ripatti, S.
(author)
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Schleutker, J.
(author)
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Arvas, M.Karolinska Institutet
(author)
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Carpen, O.
(author)
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Hinttala, R.
(author)
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Mannermaa, A.
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Aalto-Setala, K.
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Kahonen, M.
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Makela, J.
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Kalviainen, R.
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Julkunen, V.
(author)
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Soininen, H.
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Remes, A.
(author)
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Hiltunen, M.
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Peltola, J.
(author)
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Raivio, M.
(author)
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Tienari, P.
(author)
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Rinne, J.
(author)
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Kallionpaa, R.
(author)
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Partanen, J.
(author)
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Abbasi, A.
(author)
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Ziemann, A.
(author)
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Smaoui, N.
(author)
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Lehtonen, A.
(author)
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Eaton, S.
(author)
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Lahdenpera, S.
(author)
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Bowers, N.
(author)
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Teng, E.
(author)
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Xu, F. L.
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Addis, L.
(author)
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Eicher, J.
(author)
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Li, Q. Q. S.
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He, K.
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Khramtsova, E.
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Farkkila, M.
(author)
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Koskela, J.
(author)
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Pikkarainen, S.
(author)
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Jussila, A.
(author)
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Kaukinen, K.
(author)
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Blomster, T.
(author)
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Kiviniemi, M.
(author)
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Voutilainen, M.
(author)
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Lu, T.
(author)
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McCarthy, L.
(author)
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Hart, A.
(author)
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Guan, M. J.
(author)
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Miller, J.
(author)
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Kalpala, K.
(author)
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Miller, M.
(author)
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Eklund, K.
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Palomaki, A.
(author)
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Isomaki, P.
(author)
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Pirila, L.
(author)
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Kaipiainen-Seppanen, O.
(author)
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Huhtakangas, J.
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Mars, N.
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Lertratanakul, A.
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Hochfeld, M.
(author)
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Gordillo, J. E.
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Farias, F.
(author)
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Bing, N.
(author)
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Pelkonen, M.
(author)
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Kauppi, P.
(author)
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Kankaanranta, Hannu,1967Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xkankh
(author)
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Harju, T.
(author)
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Lahesmaa, R.
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Lassi, G.
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Chen, H.
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Betts, J.
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Mishra, R.
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Mouded, M.
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Ngo, D.
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Niiranen, T.
(author)
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Vaura, F.
(author)
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Salomaa, V.
(author)
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Metsarinne, K.
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Aittokallio, J.
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Hernesniemi, J.
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Gordin, D.
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Sinisalo, J.
(author)
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Taskinen, M. R.
(author)
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Tuomi, T.
(author)
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Hiltunen, T.
(author)
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Elliott, A.
(author)
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Reeve, M. P.
(author)
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Ruotsalainen, S.
(author)
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Challis, B.
(author)
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Chu, A.
(author)
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Reilly, D.
(author)
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Mendelson, M.
(author)
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Parkkinen, J.
(author)
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Meretoja, T.
(author)
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Joensuu, H.
(author)
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Mattson, J.
(author)
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Salminen, E.
(author)
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Auranen, A.
(author)
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Karihtala, P.
(author)
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Auvinen, P.
(author)
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Elenius, K.
(author)
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Pitkanen, E.
(author)
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Popovic, R.
(author)
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Schutzman, J.
(author)
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Kulkarni, D.
(author)
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Porello, A.
(author)
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Loboda, A.
(author)
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Lehtonen, H.
(author)
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McDonough, S.
(author)
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Vuoti, S.
(author)
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Kaarniranta, K.
(author)
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Turunen, J. A.
(author)
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Ollila, T.
(author)
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Uusitalo, H.
(author)
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Karjalainen, J.
(author)
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Liu, M. Z.
(author)
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Loomis, S.
(author)
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Strauss, E.
(author)
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Chen, H.
(author)
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Tasanen, K.
(author)
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Huilaja, L.
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Hannula-Jouppi, K.
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Salmi, T.
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Peltonen, S.
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Koulu, L.
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Choy, D.
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Wu, Y.
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Pussinen, P.
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Salminen, A.
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Salo, T.
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Rice, D.
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Nieminen, P.
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Palotie, U.
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Siponen, M.
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Suominen, L.
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Mantyla, P.
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Gursoy, U.
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Anttonen, V.
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Sipila, K.
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Laivuori, H.
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Kurra, V.
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Kotaniemi-Talonen, L.
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Heikinheimo, O.
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Kalliala, I.
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Aaltonen, L.
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Jokimaa, V.
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Vaarasmaki, M.
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Morin-Papunen, L.
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Niinimaki, M.
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Piltonen, T.
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Kivinen, K.
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Widen, E.
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Tukiainen, T.
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Valimaki, N.
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Laakkonen, E.
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Silven, H.
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Arffman, R.
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Savukoski, S.
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Laisk, T.
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Pujol, N.
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Kumar, J.
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Hovatta, I.
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Isometsa, E.
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Ollila, H.
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Suvisaari, J.
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Als, T. D.
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Makitie, A.
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Bizaki-Vallaskangas, A.
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Toppila-Salmi, S.
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Willberg, T.
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Saarentaus, E.
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Aarnisalo, A.
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Rahikkala, E.
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Aittomaki, K.
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Aberg, F.
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Kurki, M.
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Havulinna, A.
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Mehtonen, J.
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Palta, P.
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Hassan, S.
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Parolo, P. D.
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Zhou, W.
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Maasha, M.
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Lemmela, S.
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Liu, A. X.
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Lehisto, A.
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Ganna, A.
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Llorens, V.
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Heyne, H.
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Ramo, J.
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Rodosthenous, R.
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Strausz, S.
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Palotie, T.
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Palin, K.
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Garcia-Tabuenca, J.
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Siirtola, H.
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Kiiskinen, T.
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Lee, J.
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Tsuo, K.
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Kristiansson, K.
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Hyvarinen, K.
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Ritari, J.
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Pylkas, K.
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Karjalainen, M.
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Mantere, T.
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Kangasniemi, E.
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Heikkinen, S.
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Pitkanen, N.
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Lessard, S.
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Chatelain, C.
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Terho, P.
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Wahlfors, T.
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Punkka, E.
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Siltanen, S.
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Kuopio, T.
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Jalanko, A.
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Shen, H. Y.
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Kajanne, R.
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Aavikko, M.
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Palin, H.
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Linna, M. M.
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Kanai, M.
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Zheng, Z. L.
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Lahtela, L. E.
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Kaunisto, M.
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Kilpelainen, E.
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Sipila, T. P.
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Dada, O. A.
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Ghazal, A.
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Kytola, A.
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Weldatsadik, R.
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Donner, K.
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Loukola, A.
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Laiho, P.
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Sistonen, T.
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Kaiharju, E.
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Laukkanen, M.
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Jarvensivu, E.
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Lahteenmaki, S.
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Mannikko, L.
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Wong, R.
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Toivola, A.
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Brunfeldt, M.
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Mattsson, H.
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Koskelainen, S.
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Hiekkalinna, T.
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Paajanen, T.
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Parn, K.
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Kals, M.
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Luo, S.
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Padmanabhuni, S. S.
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Niemi, M.
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Gracia-Tabuenca, J.
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Helminen, M.
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Luukkaala, T.
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Vahatalo, I.
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Tammerluoto, J.
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Smith, S.
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Southerington, T.
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Lehto, P.
(author)
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Karolinska InstitutetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
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In:Nature Communications: Springer Science and Business Media LLC14:12041-1723
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Sliz, E.
-
Tyrmi, J. S.
-
Rahmioglu, N.
-
Zondervan, K. T.
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Becker, C. M.
-
Uimari, O.
-
show more...
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Kettunen, J.
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Palotie, A.
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Daly, M.
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Riley-Gills, B.
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Jacob, H.
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Paul, D.
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Matakidou, A.
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Platt, A.
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Runz, H.
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John, S.
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Okafo, G.
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Lawless, N.
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Salminen-Mankone ...
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Plenge, R.
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Maranville, J.
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McCarthy, M.
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Ehm, M. G.
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Auro, K.
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Longerich, S.
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Fox, C.
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Malarstig, A.
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Klinger, K.
-
Chatelain, C.
-
Gossel, M.
-
Estrada, K.
-
Graham, R.
-
Yang, R.
-
O'Donnell, C.
-
Makela, T. P.
-
Kaprio, J.
-
Virolainen, P.
-
Hakanen, A.
-
Kilpi, T.
-
Perola, M.
-
Partanen, J.
-
Pitkaranta, A.
-
Raivio, T.
-
Serpi, R.
-
Laitinen, T.
-
Kosma, V. M.
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Laukkanen, J.
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Hautalahti, M.
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Tuovila, O.
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Pakkanen, R.
-
Waring, J.
-
Riley-Gillis, B.
-
Rahimov, F.
-
Tachmazidou, I.
-
Chen, C. Y.
-
Ding, Z. H.
-
Jung, M.
-
Biswas, S.
-
Pendergrass, R.
-
Pulford, D.
-
Raghavan, N.
-
Huertas-Vazquez, ...
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Sul, J. H.
-
Hu, X. L.
-
Hedman, A.
-
Rivas, M.
-
Waterworth, D.
-
Renaud, N.
-
Obeidat, M.
-
Ripatti, S.
-
Schleutker, J.
-
Arvas, M.
-
Carpen, O.
-
Hinttala, R.
-
Mannermaa, A.
-
Aalto-Setala, K.
-
Kahonen, M.
-
Makela, J.
-
Kalviainen, R.
-
Julkunen, V.
-
Soininen, H.
-
Remes, A.
-
Hiltunen, M.
-
Peltola, J.
-
Raivio, M.
-
Tienari, P.
-
Rinne, J.
-
Kallionpaa, R.
-
Abbasi, A.
-
Ziemann, A.
-
Smaoui, N.
-
Lehtonen, A.
-
Eaton, S.
-
Lahdenpera, S.
-
Bowers, N.
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Teng, E.
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Xu, F. L.
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Addis, L.
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Eicher, J.
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Li, Q. Q. S.
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He, K.
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Khramtsova, E.
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Farkkila, M.
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Koskela, J.
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Pikkarainen, S.
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Jussila, A.
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Kaukinen, K.
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Blomster, T.
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Kiviniemi, M.
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Voutilainen, M.
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Lu, T.
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McCarthy, L.
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Hart, A.
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Guan, M. J.
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Miller, J.
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Kalpala, K.
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Niiranen, T.
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Vaura, F.
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Salomaa, V.
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Metsarinne, K.
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Aittokallio, J.
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Taskinen, M. R.
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Hiltunen, T.
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Elliott, A.
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Reeve, M. P.
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Ruotsalainen, S.
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Challis, B.
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Chu, A.
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Reilly, D.
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Mendelson, M.
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Parkkinen, J.
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Joensuu, H.
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Salminen, E.
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Auranen, A.
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Karihtala, P.
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Auvinen, P.
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Elenius, K.
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Pitkanen, E.
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Popovic, R.
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Schutzman, J.
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Kulkarni, D.
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Porello, A.
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Loboda, A.
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Lehtonen, H.
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McDonough, S.
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Vuoti, S.
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Kaarniranta, K.
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Turunen, J. A.
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Ollila, T.
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Uusitalo, H.
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Karjalainen, J.
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Liu, M. Z.
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Loomis, S.
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Salo, T.
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Nieminen, P.
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Palotie, U.
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- MEDICAL AND HEALTH SCIENCES
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University of Gothenburg
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