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Can single-cell and spatial omics unravel the pathophysiology of pre-eclampsia?

Hartmann, S. (author)
Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.;DZHK German Ctr Cardiovasc Res, Partner site Berlin, Berlin, Germany.
Botha, S. M. (author)
Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.
Gray, C. M. (author)
Stellenbosch Univ, Biomed Res Inst, Div Mol Biol & Human Genet, ZA-7505 Cape Town, South Africa.
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Valdes, D. S. (author)
Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.
Tong, S. P. (author)
Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.
Kaituu-Lino, T. J. (author)
Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.
Herse, F. (author)
Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.
Bergman, Lina, 1982 (author)
Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynaecol, ZA-7505 Cape Town, South Africa.;Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Obstet & Gynaecol, S-40530 Gothenburg, Sweden.
Cluver, C. A. (author)
Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Stellenbosch Univ, Dept Obstet & Gynaecol, ZA-7505 Cape Town, South Africa.
Dechend, R. (author)
Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.;DZHK German Ctr Cardiovasc Res, Partner site Berlin, Berlin, Germany.;HELIOS Clin, Dept Cardiol & Nephrol, Berlin, Germany.
Nonn, O. (author)
Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.;DZHK German Ctr Cardiovasc Res, Partner site Berlin, Berlin, Germany.;Med Univ Graz, Gottfried Schatz Res Ctr, Div Cell Biol Histol & Embryol, Graz, Austria.
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Charite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany.;DZHK German Ctr Cardiovasc Res, Partner site Berlin, Berlin, Germany. Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Expt & Clin Res Ctr, Berlin, Germany.;Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Berlin, Germany. (creator_code:org_t)
Elsevier, 2023
2023
English.
In: Journal of Reproductive Immunology. - : Elsevier. - 0165-0378 .- 1872-7603. ; 159
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Pre-eclampsia is a leading cause of maternal and fetal morbidity and mortality. Characterised by the onset of hypertension and proteinuria in the second half of pregnancy, it can lead to maternal end-organ injury such as cerebral ischemia and oedema, pulmonary oedema and renal failure, and potentially fatal outcomes for both mother and fetus. The causes of the different maternal end-organ phenotypes of pre-eclampsia and why some women develop pre-eclampsia condition early in pregnancy have yet to be elucidated. Omics methods include proteomics, genomics, metabolomics, transcriptomics. These omics techniques, previously mostly used on bulk tissue and individually, are increasingly available at a single cellular level and can be combined with each other. Multi-omics techniques on a single-cell or spatial level provide us with a powerful tool to understand the pathophysiology of pre-eclampsia. This review will explore the status of omics methods and how they can and could contribute to understanding the pathophysiology of pre-eclampsia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Keyword

Pre-eclampsia
Single-cell RNA-seq
Multi-omics
Spatial omics
Placenta
Pre-eclampsia

Publication and Content Type

ref (subject category)
art (subject category)

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