The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea

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Bikov, A. (author)

The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea

Article/chapterEnglish2024

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2024

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LIBRIS-ID:oai:gup.ub.gu.se/330854
https://gup.ub.gu.se/publication/330854URI
https://doi.org/10.1111/jsr.14012DOI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Periodic limb movements during sleep and obstructive sleep apnea are both associated with increased sympathetic tone, and have been proposed as risk factors for heart diseases and, in particular, cardiovascular disease. As sympathetic system activation may lead to dyslipidaemia, periodic limb movements during sleep could be an additional risk factor for cardiovascular disease in patients with obstructive sleep apnea. The aim of the study was to determine whether the presence of periodic limb movements during sleep affects serum lipid levels in obstructive sleep apnea. Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non- high-density lipoprotein cholesterol and triglyceride levels were investigated in 4138 patients with obstructive sleep apnea in the European Sleep Apnea Database (ESADA) cohort, divided into those with periodic limb movements during sleep index & GE; 15 per hr (n = 628) and controls (n = 3510). ANCOVA adjusted for age, sex, body mass index, apnea-hypopnea index, alcohol intake, smoking status, diabetes, insomnia and study site was used to assess differences in lipids between periodic limb movements during sleep and controls. Patients with periodic limb movements during sleep (24% female, 54.4 & PLUSMN; 12.1 years, body mass index 31.9 & PLUSMN; 5.8 kg m(-2), apnea-hypopnea index 36.7 & PLUSMN; 25.4 per hr) had higher triglyceride (1.81 & PLUSMN; 1.04 versus 1.69 & PLUSMN; 0.90 mmol L-1, p = 0.002) and lower high-density lipoprotein cholesterol (1.19 & PLUSMN; 0.34 versus 1.24 & PLUSMN; 0.37 mmol L-1, p = 0.002) levels, whilst there was no difference in either total cholesterol (4.98 & PLUSMN; 1.10 versus 4.94 & PLUSMN; 1.07 mmol L-1), low-density lipoprotein cholesterol (3.04 & PLUSMN; 0.96 versus 2.98 & PLUSMN; 0.98 mmol L-1) or non- high-density lipoprotein cholesterol (3.78 & PLUSMN; 1.10 versus 3.70 & PLUSMN; 1.05 mmol L-1) concentrations (all p > 0.05). The results remained unchanged after most sensitivity analyses. Patients with obstructive sleep apnea with periodic limb movements during sleep had more prevalent cardiovascular disease (11% versus 6%, p < 0.01). Periodic limb movements during sleep in obstructive sleep apnea is associated with dyslipidaemia independently of important confounders. Our results highlight periodic limb movements during sleep as an additional risk factor for cardiovascular disease in obstructive sleep apnea.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
apnea
cardiovascular disease
lipids
sleep
restless legs syndrome
density-lipoprotein cholesterol
cardiovascular
risk-factors
positive airway pressure
disease
hypertension
prevalence
association
mortality
therapy
Neurosciences & Neurology

Added entries (persons, corporate bodies, meetings, titles ...)

Bailly, S. (author)
Testelmans, D. (author)
Fanfulla, F. (author)
Pataka, A. (author)
Bouloukaki, I. (author)
Hein, H. (author)
Dogas, Z. (author)
Basoglu, O. K. (author)
Staats, R. (author)
Parati, G. (author)
Lombardi, C. (author)
Grote, Ludger,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xgrolu (author)
Mihaicuta, S. (author)
Esada Study Grp, Esada Study Grp (author)
Göteborgs universitetInstitutionen för medicin (creator_code:org_t)

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In:Journal of Sleep Research33:20962-11051365-2869

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By the author/editor: Bikov, A.; Bailly, S.; Testelmans, D.; Fanfulla, F.; Pataka, A.; Bouloukaki, I.; show more...; Hein, H.; Dogas, Z.; Basoglu, O. K.; Staats, R.; Parati, G.; Lombardi, C.; Grote, Ludger, 1 ...; Mihaicuta, S.; Esada Study Grp, ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Journal of Sleep ...

By the university: University of Gothenburg

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