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Associations betwee...
Associations between recall of proper names in story recall and CSF amyloid and tau in adults without cognitive impairment.
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Hale, Madeline R (author)
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Langhough, Rebecca (author)
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Du, Lianlian (author)
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Hermann, Bruce P (author)
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Van Hulle, Carol A (author)
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Carboni, Margherita (author)
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Kollmorgen, Gwendlyn (author)
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Basche, Kristin E (author)
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Bruno, Davide (author)
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Sanson-Miles, Leah (author)
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Jonaitis, Erin M (author)
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Chin, Nathaniel A (author)
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Okonkwo, Ozioma C (author)
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Bendlin, Barbara B (author)
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Carlsson, Cynthia M (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Betthauser, Tobey J (author)
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Johnson, Sterling C (author)
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Mueller, Kimberly D (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Neurobiology of aging. - 1558-1497. ; 133, s. 87-98
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Abstract
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- Neuropsychological measures sensitive to decline in the preclinical phase of Alzheimer's diseaseare needed. We previously demonstrated that higher amyloid-beta (Aβ) assessed by positron emission tomography in adults without cognitive impairment was associated with recall of fewer proper names in Logical Memory story recall. The current study investigated the association between proper names and cerebrospinal fluidbiomarkers (Aβ42/40, phosphorylated tau181 [pTau181], neurofilament light) in 223 participants from the Wisconsin Registry for Alzheimer's Prevention. We assessed associations between biomarkers and delayed Logical Memory total score and proper names using binary logistic regressions. Sensitivity analyses used multinomial logistic regression and stratified biomarker groups. Lower Logical Memory total score and proper names scores from themost recent visit were associated with biomarker positivity. Relatedly, there was a 27% decreased risk of being classified Aβ42/40+/pTau181+for each additional proper name recalled. A linear mixed effects model found that longitudinal change in proper names recall was predicted by biomarker status. These results demonstrate a novel relationship between proper names and Alzheimer's disease-cerebrospinal fluid pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Humans
- Alzheimer Disease
- pathology
- tau Proteins
- cerebrospinal fluid
- Longitudinal Studies
- Disease Progression
- Cognitive Dysfunction
- psychology
- Amyloid beta-Peptides
- cerebrospinal fluid
- Biomarkers
- cerebrospinal fluid
- Peptide Fragments
- cerebrospinal fluid
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hale, Madeline R
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Langhough, Rebec ...
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Du, Lianlian
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Hermann, Bruce P
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Van Hulle, Carol ...
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Carboni, Margher ...
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show more...
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Kollmorgen, Gwen ...
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Basche, Kristin ...
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Bruno, Davide
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Sanson-Miles, Le ...
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Jonaitis, Erin M
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Chin, Nathaniel ...
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Okonkwo, Ozioma ...
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Bendlin, Barbara ...
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Carlsson, Cynthi ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Betthauser, Tobe ...
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Johnson, Sterlin ...
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Mueller, Kimberl ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurobiology of ...
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University of Gothenburg