Search: onr:"swepub:oai:gup.ub.gu.se/330985" >
Combined immunother...
Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: A report from the International RRD Consortium.
-
Das, Anirban (author)
-
Fernandez, Nicholas R (author)
-
Levine, Adrian (author)
-
show more...
-
Bianchi, Vanessa (author)
-
Stengs, Lucie K (author)
-
Chung, Jiil (author)
-
Negm, Logine (author)
-
Dimayacyac, Jose Rafael (author)
-
Chang, Yuan (author)
-
Nobre, Liana (author)
-
Ercan, Ayse B (author)
-
Sanchez-Ramirez, Santiago (author)
-
Sudhaman, Sumedha (author)
-
Edwards, Melissa (author)
-
Larouche, Valerie (author)
-
Samuel, David (author)
-
Van Damme, An (author)
-
Gass, David (author)
-
Ziegler, David S (author)
-
Bielack, Stefan S (author)
-
Koschmann, Carl (author)
-
Zelcer, Shayna (author)
-
Yalon-Oren, Michal (author)
-
Campino, Gadi Abede (author)
-
Sarosiek, Tomasz (author)
-
Nichols, Kim E (author)
-
Loret De Mola, Rebecca (author)
-
Bielamowicz, Kevin (author)
-
- Sabel, Magnus, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
Frojd, Charlotta A (author)
-
Wood, Matthew D (author)
-
Glover, Jason M (author)
-
Lee, Yi-Yen (author)
-
Vanan, Magimairajan (author)
-
Adamski, Jenny K (author)
-
Perreault, Sebastien (author)
-
Chamdine, Omar (author)
-
Hjort, Magnus Aasved (author)
-
Zapotocky, Michal (author)
-
Carceller, Fernando (author)
-
Wright, Erin (author)
-
Fedorakova, Ivana (author)
-
Lossos, Alexander (author)
-
Tanaka, Ryuma (author)
-
Osborn, Michael (author)
-
Blumenthal, Deborah T (author)
-
Aronson, Melyssa (author)
-
Bartels, Ute (author)
-
Huang, Annie (author)
-
Ramaswamy, Vijay (author)
-
Malkin, David (author)
-
Shlien, Adam (author)
-
Villani, Anita (author)
-
Dirks, Peter B (author)
-
Pugh, Trevor J (author)
-
Getz, Gad (author)
-
Maruvka, Yosef E (author)
-
Tsang, Derek S (author)
-
Ertl-Wagner, Birgit (author)
-
Hawkins, Cynthia (author)
-
Bouffet, Eric (author)
-
Morgenstern, Daniel A (author)
-
Tabori, Uri (author)
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Cancer discovery. - 2159-8290. ; 14:2, s. 258-273
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Immune-checkpoint inhibition (ICI) is effective for replication-repair deficient, high-grade gliomas (RRD-HGG). Clinical/biologic impact of immune-directed approaches after failing ICI-monotherapy are unknown. We performed an international study on 75 patients treated with anti-PD1; 20 are progression-free (median follow-up: 3.7-years). After 2nd-progression/recurrence (n=55), continuing ICI-based salvage prolonged survival to 11.6-months (n=38; p<0.001), particularly for those with extreme mutation burden (p=0.03). Delayed, sustained responses were observed, associated with changes in mutational spectra and immune-microenvironment. Response to re-irradiation was explained by an absence of deleterious post-radiation indel signatures (ID8). Increased CTLA4-expression over time, and subsequent CTLA4-inhibition resulted in response/stable disease in 75%. RAS-MAPK-pathway inhibition led to reinvigoration of peripheral immune and radiological responses. Local (flare) and systemic immune adverse events were frequent (biallelic mismatch-repair deficiency > Lynch syndrome). We provide mechanistic rationale for the sustained benefit in RRD-HGG from immune-directed/ synergistic salvage therapies. Future approaches need to be tailored to patient and tumor biology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Das, Anirban
-
Fernandez, Nicho ...
-
Levine, Adrian
-
Bianchi, Vanessa
-
Stengs, Lucie K
-
Chung, Jiil
-
show more...
-
Negm, Logine
-
Dimayacyac, Jose ...
-
Chang, Yuan
-
Nobre, Liana
-
Ercan, Ayse B
-
Sanchez-Ramirez, ...
-
Sudhaman, Sumedh ...
-
Edwards, Melissa
-
Larouche, Valeri ...
-
Samuel, David
-
Van Damme, An
-
Gass, David
-
Ziegler, David S
-
Bielack, Stefan ...
-
Koschmann, Carl
-
Zelcer, Shayna
-
Yalon-Oren, Mich ...
-
Campino, Gadi Ab ...
-
Sarosiek, Tomasz
-
Nichols, Kim E
-
Loret De Mola, R ...
-
Bielamowicz, Kev ...
-
Sabel, Magnus, 1 ...
-
Frojd, Charlotta ...
-
Wood, Matthew D
-
Glover, Jason M
-
Lee, Yi-Yen
-
Vanan, Magimaira ...
-
Adamski, Jenny K
-
Perreault, Sebas ...
-
Chamdine, Omar
-
Hjort, Magnus Aa ...
-
Zapotocky, Micha ...
-
Carceller, Ferna ...
-
Wright, Erin
-
Fedorakova, Ivan ...
-
Lossos, Alexande ...
-
Tanaka, Ryuma
-
Osborn, Michael
-
Blumenthal, Debo ...
-
Aronson, Melyssa
-
Bartels, Ute
-
Huang, Annie
-
Ramaswamy, Vijay
-
Malkin, David
-
Shlien, Adam
-
Villani, Anita
-
Dirks, Peter B
-
Pugh, Trevor J
-
Getz, Gad
-
Maruvka, Yosef E
-
Tsang, Derek S
-
Ertl-Wagner, Bir ...
-
Hawkins, Cynthia
-
Bouffet, Eric
-
Morgenstern, Dan ...
-
Tabori, Uri
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer discovery
- By the university
-
University of Gothenburg