Search: onr:"swepub:oai:gup.ub.gu.se/331412" >
Impact of Epithelia...
Impact of Epithelial Histological Types, Subtypes, and Growth Patterns on Oncological Outcomes for Patients with Nonmetastatic Prostate Cancer Treated with Curative Intent: A Systematic Review.
-
Marra, Giancarlo (author)
-
van Leenders, Geert J L H (author)
-
Zattoni, Fabio (author)
-
show more...
-
Kesch, Claudia (author)
-
Rajwa, Pawel (author)
-
Cornford, Philip (author)
-
van der Kwast, Theodorus (author)
-
van den Bergh, Roderick C N (author)
-
Briers, Erik (author)
-
Van den Broeck, Thomas (author)
-
De Meerleer, Gert (author)
-
De Santis, Maria (author)
-
Eberli, Daniel (author)
-
Farolfi, Andrea (author)
-
Gillessen, Silke (author)
-
Grivas, Nikolaos (author)
-
Grummet, Jeremy P (author)
-
Henry, Ann M (author)
-
Lardas, Michael (author)
-
Lieuw, Matt (author)
-
Linares Espinós, Estefania (author)
-
Mason, Malcolm D (author)
-
O'Hanlon, Shane (author)
-
van Oort, Inge M (author)
-
Oprea-Lager, Daniela E (author)
-
Ploussard, Guillaume (author)
-
Rouvière, Olivier (author)
-
Schoots, Ivo G (author)
-
- Stranne, Johan, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
-
Tilki, Derya (author)
-
Wiegel, Thomas (author)
-
Willemse, Peter-Paul M (author)
-
Mottet, Nicolas (author)
-
Gandaglia, Giorgio (author)
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: European urology. - 0302-2838 .- 1873-7560. ; 84:1, s. 65-85
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The optimal management for men with prostate cancer (PCa) with unconventional histology (UH) is unknown. The outcome for these cancers might be worse than for conventional PCa and so different approaches may be needed.To compare oncological outcomes for conventional and UH PCa in men with localized disease treated with curative intent.A systematic review adhering to the Referred Reporting Items for Systematic Reviews and Meta-Analyses was prospectively registered on PROSPERO (CRD42022296013) was performed in July 2021.We screened 3651 manuscripts and identified 46 eligible studies (reporting on 1871814 men with conventional PCa and 6929 men with 10 different PCa UHs). Extraprostatic extension and lymph node metastases, but not positive margin rates, were more common with UH PCa than with conventional tumors. PCa cases with cribriform pattern, intraductal carcinoma, or ductal adenocarcinoma had higher rates of biochemical recurrence and metastases after radical prostatectomy than for conventional PCa cases. Lower cancer-specific survival rates were observed for mixed cribriform/intraductal and cribriform PCa. By contrast, pathological findings and oncological outcomes for mucinous and prostatic intraepithelial neoplasia (PIN)-like PCa were similar to those for conventional PCa. Limitations of this review include low-quality studies, a risk of reporting bias, and a scarcity of studies that included radiotherapy.Intraductal, cribriform, and ductal UHs may have worse oncological outcomes than for conventional and mucinous or PIN-like PCa. Alternative treatment approaches need to be evaluated in men with these cancers.We reviewed the literature to explore whether prostate cancers with unconventional growth patterns behave differently to conventional prostate cancers. We found that some unconventional growth patterns have worse outcomes, so we need to investigate if they need different treatments. Urologists should be aware of these growth patterns and their clinical impact.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Humans
- Male
- Prostate
- surgery
- pathology
- Prostate-Specific Antigen
- Prostatectomy
- Prostatic Intraepithelial Neoplasia
- Prostatic Neoplasms
- pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Marra, Giancarlo
-
van Leenders, Ge ...
-
Zattoni, Fabio
-
Kesch, Claudia
-
Rajwa, Pawel
-
Cornford, Philip
-
show more...
-
van der Kwast, T ...
-
van den Bergh, R ...
-
Briers, Erik
-
Van den Broeck, ...
-
De Meerleer, Ger ...
-
De Santis, Maria
-
Eberli, Daniel
-
Farolfi, Andrea
-
Gillessen, Silke
-
Grivas, Nikolaos
-
Grummet, Jeremy ...
-
Henry, Ann M
-
Lardas, Michael
-
Lieuw, Matt
-
Linares Espinós, ...
-
Mason, Malcolm D
-
O'Hanlon, Shane
-
van Oort, Inge M
-
Oprea-Lager, Dan ...
-
Ploussard, Guill ...
-
Rouvière, Olivie ...
-
Schoots, Ivo G
-
Stranne, Johan, ...
-
Tilki, Derya
-
Wiegel, Thomas
-
Willemse, Peter- ...
-
Mottet, Nicolas
-
Gandaglia, Giorg ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
European urology
- By the university
-
University of Gothenburg