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Fracture Incidence ...
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Khamisi, SelwanUppsala University,Uppsala University Hospital
(author)
Fracture Incidence in Graves' Disease: A Population-Based Study.
- Article/chapterEnglish2023
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/331453
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https://gup.ub.gu.se/publication/331453URI
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https://doi.org/10.1089/thy.2023.0162DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108380URI
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https://lup.lub.lu.se/record/36af9e36-7412-4919-b094-fb37aa6caaa1URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:237725590URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The aim of this study was to investigate fracture risk in patients with GD. Methods: A total of 2134 patients with incident GD and 21,261 age, sex- and county-matched controls were included 16-18 years after diagnosis in a retrospective cohort study. Drug and patient national registries in Sweden were used to assess the risk of developing skeletal complications. Up to 10 years of age, sex- and county-matched controls per patient were selected from databases from the National Board of Health and Welfare and Statistics Sweden. Cox proportional hazards models were fitted to estimate hazard ratios (HR) and confidence intervals [CI]. Results: There were no significant differences in fracture rates between GD and controls but after adjustment for comorbidities, the data showed higher vertebral fracture rates in male GD patients aged >52 years compared to male controls, HR=2.83 [CI 1.05-7.64]. The rates of osteoporosis treatments as well as treatment with corticosteroids were higher in patients with GD. However, HR for the association between GD and fractures remained largely unchanged after adjustment for osteoporosis treatments and treatments with corticosteroids. Conclusions: There were no significant differences in total fracture rate between GD and the general population. However, men older than 52 years had a higher vertebral fracture rate. This study also shows that patients with treated GD receive more osteoporosis treatments compared to the general population.
Subject headings and genre
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Udumyan, Ruzan,1971-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)run
(author)
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Sjölin, Gabriel,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro University Hospital(Swepub:oru)glsn
(author)
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Calissendorff, JanKarolinska Institutet,Karolinska Institute
(author)
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Nyström, Helena Filipsson,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy, 70712, Dept. of Endocrinology, Sahlgrenska University Hospital, Goteborg, Sweden(Swepub:gu)xfilih
(author)
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Holmberg, Mikael,1950Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
(author)
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Hallengren, BengtLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-bha
(author)
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Lantz, MikaelLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-mla
(author)
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Planck, TerezaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-tvo
(author)
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Wallin, Göran,1952-Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Institutet, 27106, Department of Molecular Medicine and Surgery, Stockholm, Sweden; Departgment of Surgery(Swepub:oru)gwn
(author)
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Ljunggren, ÖstenUppsala University
(author)
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Holmberg, MatsSahlgrenska Academy, 70712, Goteborg, Sweden
(author)
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Uppsala UniversityUppsala University Hospital
(creator_code:org_t)
Related titles
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In:Thyroid : official journal of the American Thyroid Association: Mary Ann Liebert33:11, s. 1349-13571557-90771050-7256
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