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Questioning the fet...
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
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Kennedy, K. M. (author)
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de Goffau, M. C. (author)
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Perez-Munoz, M. E. (author)
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show more...
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Arrieta, M. C. (author)
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Bork, P. (author)
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Braun, T. (author)
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Bushman, F. D. (author)
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Dore, J. (author)
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de Vos, W. M. (author)
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Earl, A. M. (author)
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Eisen, J. A. (author)
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Elovitz, M. A. (author)
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Ganal-Vonarburg, S. C. (author)
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Ganzle, M. G. (author)
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Garrett, W. S. (author)
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Hall, L. J. (author)
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Hornef, M. W. (author)
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Huttenhower, C. (author)
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Konnikova, L. (author)
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Lebeer, S. (author)
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Macpherson, A. J. (author)
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Massey, R. C. (author)
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McHardy, A. C. (author)
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Koren, O. (author)
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Lawley, T. D. (author)
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Ley, R. E. (author)
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O'Mahony, L. (author)
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O'Toole, P. W. (author)
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Pamer, E. G. (author)
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Parkhill, J. (author)
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Raes, J. (author)
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Rattei, T. (author)
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Salonen, A. (author)
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Segal, E. (author)
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Segata, N. (author)
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Shanahan, F. (author)
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Sloboda, D. M. (author)
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Smith, G. C. S. (author)
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Sokol, H. (author)
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Spector, T. D. (author)
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Surette, M. G. (author)
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Tannock, G. W. (author)
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Walker, A. W. (author)
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Yassour, M. (author)
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Walter, J. (author)
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(creator_code:org_t)
- 2023-01-25
- 2023
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 613:7945, s. 639-649
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluate recent studies that characterized microbial populations in human fetuses from the perspectives of reproductive biology, microbial ecology, bioinformatics, immunology, clinical microbiology and gnotobiology, and assess possible mechanisms by which the fetus might interact with microorganisms. Our analysis indicates that the detected microbial signals are likely the result of contamination during the clinical procedures to obtain fetal samples or during DNA extraction and DNA sequencing. Furthermore, the existence of live and replicating microbial populations in healthy fetal tissues is not compatible with fundamental concepts of immunology, clinical microbiology and the derivation of germ-free mammals. These conclusions are important to our understanding of human immune development and illustrate common pitfalls in the microbial analyses of many other low-biomass environments. The pursuit of a fetal microbiome serves as a cautionary example of the challenges of sequence-based microbiome studies when biomass is low or absent, and emphasizes the need for a trans-disciplinary approach that goes beyond contamination controls by also incorporating biological, ecological and mechanistic concepts.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- amniotic cavity
- lactobacillus
- transmission
- invasion
- shapes
- contamination
- pregnancies
- infections
- community
- bacteria
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Kennedy, K. M.
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de Goffau, M. C.
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Perez-Munoz, M. ...
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Arrieta, M. C.
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Bäckhed, Fredrik ...
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Bork, P.
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show more...
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Braun, T.
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Bushman, F. D.
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Dore, J.
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de Vos, W. M.
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Earl, A. M.
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Eisen, J. A.
-
Elovitz, M. A.
-
Ganal-Vonarburg, ...
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Ganzle, M. G.
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Garrett, W. S.
-
Hall, L. J.
-
Hornef, M. W.
-
Huttenhower, C.
-
Konnikova, L.
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Lebeer, S.
-
Macpherson, A. J ...
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Massey, R. C.
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McHardy, A. C.
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Koren, O.
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Lawley, T. D.
-
Ley, R. E.
-
O'Mahony, L.
-
O'Toole, P. W.
-
Pamer, E. G.
-
Parkhill, J.
-
Raes, J.
-
Rattei, T.
-
Salonen, A.
-
Segal, E.
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Segata, N.
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Shanahan, F.
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Sloboda, D. M.
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Smith, G. C. S.
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Sokol, H.
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Spector, T. D.
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Surette, M. G.
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Tannock, G. W.
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Walker, A. W.
-
Yassour, M.
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Walter, J.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature
- By the university
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University of Gothenburg