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Haematopoietic stem...
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Silfverberg, ThomasUppsala universitet,Uppsala University,Center for Clinical Research Dalarna,Centrum för klinisk forskning Dalarna,Hematologi
(author)
Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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BMJ Publishing Group Ltd,2023
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/331839
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https://gup.ub.gu.se/publication/331839URI
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https://doi.org/10.1136/jnnp-2023-331864DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108563URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153743742URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198393URI
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https://lup.lub.lu.se/record/48351675-aed2-43af-ac24-7553fcf3ae26URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-528598URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|This study was presented as an abstract and oral presentation at the European Society for Blood and Marrow Transplantation 49th Annual Meeting, Paris, 23-26 April 2023.
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BackgroundA growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare.MethodsWe assessed 231 patients and the final analysis included 174 RRMS patients who were treated with aHSCT in Sweden before 1 January 2020. Efficacy was evaluated by performing a retrospective analysis of prospectively collected data from the Swedish MS registry. Procedure-related safety was assessed by analysing data from electronic patient records covering a period of 100 days following aHSCT.ResultsWith a median follow-up time of 5.5 (IQR: 3.4-7.5) years, the Kaplan-Meier estimate for no evidence of disease activity was 73% (95% CI 66% to 81%) at 5 years and 65% (95% CI 57% to 75%) at 10 years. Out of the 149 patients with baseline disability, 80 (54%) improved, 55 (37%) were stable and 14 (9%) deteriorated. The mean number of adverse events per patient was 1.7 (& PLUSMN;SD: 1.5) for grade 3 events and 0.06 (& PLUSMN;SD: 0.3) for grade 4 events. Febrile neutropenia was the most common adverse event, affecting 68% of patients. There was no treatment-related mortality.ConclusionsTreatment with aHSCT for RRMS is associated with freedom from disease activity in a majority of patients, with acceptable adverse events. This procedure should be considered a standard of care for patients with highly active RRMS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Zjukovskaja, ChristinaUppsala universitet,Uppsala University,Experimentell neurologi(Swepub:uu)chrzh593
(author)
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Ljungman, P.Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ, Karolinska Comprehens Canc Ctr, Dept Cellular Therapy & Allogene Stem Cell Transpl, Hosp Huddinge, Stockholm, Sweden.,Karolinska University Hospital
(author)
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Nahimi, AdjmalLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Restorative Parkinson Unit,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Neurol Rehabil Med Memory Disorders & Geriatr, Lund, Sweden.(Swepub:lu)ad7381na
(author)
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Ahlstrand, Erik,1974-Örebro University,Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Medicine,Örebro Univ, Fac Med & Hlth, Dept Med, Örebro, Sweden.(Swepub:oru)ead
(author)
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Dreimane, ArtaDepartment of Hematology, Linköping University Hospital, Linköping, Sweden,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.(Swepub:liu)artdr13
(author)
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Einarsdottir, SigrunUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Hematology and Coagulation, Sahlgrenska Sjukhuset, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Hematol & Coagulat, Gothenburg, Sweden.,Sahlgrenska University Hospital(Swepub:gu)xeinsi
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Fagius, JanUppsala universitet,Uppsala University,Neurologi(Swepub:uu)janfagiu
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Iacobaeus, E.Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden.,Karolinska University Hospital
(author)
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Hägglund, HansUppsala universitet,Uppsala University,Karolinska University Hospital,Hematologi,Karolinska Univ, Karolinska Comprehens Canc Ctr, Dept Cellular Therapy & Allogene Stem Cell Transpl, Hosp Huddinge, Stockholm, Sweden.(Swepub:uu)hanha689
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Lange, Niclas,1990-Örebro University,Örebro Univ, Fac Med & Hlth, Dept Med, Örebro, Sweden.(Swepub:oru)nle
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Lenhoff, StigLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp Lund, Dept Hematol Oncol & Radiophys, Lund, Sweden.(Swepub:lu)med-slf
(author)
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Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden,Sahlgrens Acad, Dept Clin Neurosci, Inst Neurosci & Physiol, Gothenburg, Sweden.(Swepub:gu)xlycja
(author)
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Mellergård, JohanLinköping University,Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Linköping Univ, Dept Neurol, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.(Swepub:liu)johme15
(author)
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Piehl, F.Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden.,Karolinska University Hospital
(author)
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Svenningsson, A.Karolinska Institutet,Karolinska Inst, Dept Clin Sci, Institutionen Kliniska Vetenskaper, Danderyds Sjukhus, Stockholm, Sweden.;Karolinska Inst, Dept Neurol, Institutionen Kliniska Vetenskaper, Danderyds Sjukhus, Stockholm, Sweden.,Danderyd Hospital
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Tolf, AndreasUppsala universitet,Uppsala University,Experimentell neurologi(Swepub:uu)andto164
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Cherif, HonarUppsala universitet,Uppsala University,Hematologi(Swepub:uu)honch489
(author)
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Carlson, KristinaUppsala universitet,Uppsala University,Hematologi(Swepub:uu)krica965
(author)
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Burman, Joachim,1974-Uppsala universitet,Uppsala University,Experimentell neurologi(Swepub:uu)joabu293
(author)
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Uppsala UniversityCenter for Clinical Research Dalarna
(creator_code:org_t)
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In:Journal of Neurology Neurosurgery and Psychiatry: BMJ Publishing Group Ltd0022-30501468-330X
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Silfverberg, Tho ...
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Zjukovskaja, Chr ...
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Ljungman, P.
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Nahimi, Adjmal
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Ahlstrand, Erik, ...
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Dreimane, Arta
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Einarsdottir, Si ...
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Fagius, Jan
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Iacobaeus, E.
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Hägglund, Hans
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Lange, Niclas, 1 ...
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Lenhoff, Stig
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Lycke, Jan, 1956
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Mellergård, Joha ...
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Piehl, F.
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Svenningsson, A.
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Tolf, Andreas
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Cherif, Honar
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Burman, Joachim, ...
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University of Gothenburg
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Örebro University
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Karolinska Institutet
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Linköping University
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Lund University
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Uppsala University