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Risk of Multiple Sc...
Risk of Multiple Sclerosis in People Living with HIV: An International Cohort Study.
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- McKay, Kyla A (författare)
- Karolinska Institutet
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- Wijnands, José M A (författare)
- Karolinska Institutet
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- Manouchehrinia, Ali (författare)
- Karolinska Institutet
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visa fler...
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Zhu, Feng (författare)
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Sereda, Paul (författare)
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Li, Jenny (författare)
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Ye, Monica (författare)
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Trigg, Jason (författare)
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Kooij, Katherine (författare)
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Ekström, Anna Mia (författare)
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- Gisslén, Magnus, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Hillert, Jan (författare)
- Karolinska Institutet
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Hogg, Robert S (författare)
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Tremlett, Helen (författare)
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Kingwell, Elaine (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Annals of neurology. - 1531-8249. ; 95:3, s. 487-94
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There has been interest in a possible negative association between HIV and multiple sclerosis (MS). We aimed to compare the risk of MS in a cohort of individuals living with HIV to that in the general population.Population-based health data were accessed for 2 cohorts of HIV-positive persons from Sweden and British Columbia, Canada. Incident MS was identified using MS registries or a validated algorithm applied to administrative data. Individuals with HIV were followed from 1year after the first clinical evidence of HIV or the first date of complete administrative health data (Canada= April 1, 1992 and Sweden=January 1, 2001) until the earliest of incident MS, emigration, death, or study end (Canada=March 31, 2020 and Sweden=December 31, 2018). The observed MS incidence rate in the HIV-positive cohort was compared to the expected age-, sex-, calendar year-, income-specific, and region of birth-specific rates in a randomly selected sample of >20% of each general population. The standardized incidence ratio (SIR) for MS following the first antiretroviral therapy exposure ("ART-exposed") was also calculated.The combined Sweden-Canada cohort included 29,163 (75% men) HIV-positive persons. During 242,248 person-years of follow-up, 14 incident MS cases were observed in the HIV-positive cohort, whereas 26.19 cases were expected. The SIR for MS in the HIV-positive population was 0.53 (95% confidence interval [CI]=0.32-0.90). The SIR for MS following the first ART exposure was 0.55 (95% CI=0.31-0.96).This international population-based study demonstrated a lower risk of MS among HIV-positive individuals, and HIV-positive ART-exposed individuals. These findings provide support for further exploration into the relationship among HIV, ART, and MS. ANN NEUROL 2023.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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McKay, Kyla A
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Wijnands, José M ...
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Manouchehrinia, ...
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Zhu, Feng
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Sereda, Paul
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Li, Jenny
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visa fler...
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Ye, Monica
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Trigg, Jason
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Kooij, Katherine
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Ekström, Anna Mi ...
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Gisslén, Magnus, ...
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Hillert, Jan
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Hogg, Robert S
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Tremlett, Helen
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Kingwell, Elaine
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Annals of neurol ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet