onr:"swepub:oai:gup.ub.gu.se/331885"
Search: onr:"swepub:oai:gup.ub.gu.se/331885" > Cross-sectional and...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Ally, M. (author)
Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/331885
- https://gup.ub.gu.se/publication/331885URI
- https://doi.org/10.1002/dad2.12492DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Introduction: This study examined plasma glial fibrillary acidic protein (GFAP) as a biomarker of cognitive impairment due to Alzheimer's disease (AD) with and against plasma neurofilament light chain (NfL), and phosphorylated tau (p-tau)181+231.Methods: Plasma samples were analyzed using Simoa platform for 567 participants spanning the AD continuum. Cognitive diagnosis, neuropsychological testing, and dementia severity were examined for cross-sectional and longitudinal outcomes.Results: Plasma GFAP discriminated AD dementia from normal cognition (adjusted mean difference = 0.90 standard deviation [SD]) and mild cognitive impairment (adjusted mean difference = 0.72 SD), and demonstrated superior discrimination compared to alternative plasma biomarkers. Higher GFAP was associated with worse dementia severity and worse performance on 11 of 12 neuropsychological tests. Longitudinally, GFAP predicted decline in memory, but did not predict conversion to mild cognitive impairment or dementia.Discussion: Plasma GFAP was associated with clinical outcomes related to suspected AD and could be of assistance in a plasma biomarker panel to detect in vivo AD.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Alzheimer's disease
- glial fibrillary acidic protein
- neuropsychology
- neurofilament light chain
- phosphorylated tau
- plasma biomarkers
Added entries (persons, corporate bodies, meetings, titles ...)
- Sugarman, M. A. (author)
- Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
- Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
- Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (author)
- Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit (author)
- Aparicio, H. J. (author)
- Frank, B. (author)
- Tripodis, Y. (author)
- Martin, B. (author)
- Palmisano, J. N. (author)
- Steinberg, E. G. (author)
- Simkin, I. (author)
- Farrer, L. A. (author)
- Jun, G. R. (author)
- Turk, K. W. (author)
- Budson, A. E. (author)
- O'Connor, M. K. (author)
- Au, R. (author)
- Goldstein, L. E. (author)
- Kowall, N. W. (author)
- Killiany, R. (author)
- Stern, R. A. (author)
- Stein, T. D. (author)
- McKee, A. C. (author)
- Qiu, W. Q. (author)
- Mez, J. (author)
- Alosco, M. L. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
Related titles
- In:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring15:42352-8729
Internet link
Find in a library
- Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ally, M.
- Sugarman, M. A.
- Zetterberg, Henr ...
- Blennow, Kaj, 19 ...
- Ashton, Nicholas ...
- Karikari, Thomas
- show more...
- Aparicio, H. J.
- Frank, B.
- Tripodis, Y.
- Martin, B.
- Palmisano, J. N.
- Steinberg, E. G.
- Simkin, I.
- Farrer, L. A.
- Jun, G. R.
- Turk, K. W.
- Budson, A. E.
- O'Connor, M. K.
- Au, R.
- Goldstein, L. E.
- Kowall, N. W.
- Killiany, R.
- Stern, R. A.
- Stein, T. D.
- McKee, A. C.
- Qiu, W. Q.
- Mez, J.
- Alosco, M. L.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Alzheimer's and ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
