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Treatments for hype...
Treatments for hyperemesis gravidarum: A systematic review
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- Vinnars, Marie-Therese (author)
- Umeå universitet,Obstetrik och gynekologi,Umea Univ, Sweden
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- Forslund, Maria, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Akademin, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sweden
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- Claesson, Ing-Marie (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Hedman, A. (author)
- Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden,Swedish Agcy Hlth Technol Assessment & Assessment, Sweden
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- Peira, N. (author)
- Karolinska Institutet,Swedish Agcy Hlth Technol Assessment & Assessment, Sweden
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- Olofsson, H. (author)
- Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden,Swedish Agcy Hlth Technol Assessment & Assessment, Sweden
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- Wernersson, E. (author)
- Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden,Swedish Agcy Hlth Technol Assessment & Assessment, Sweden
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- Ulfsdottir, H. (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- English.
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In: Acta Obstetricia Et Gynecologica Scandinavica. - : John Wiley & Sons. - 0001-6349 .- 1600-0412. ; 103:1, s. 13-29
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Abstract
Subject headings
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- IntroductionHyperemesis gravidarum affects 0.3%-3% of pregnant women each year and is the leading cause of hospitalization in early pregnancy. Previous systematic reviews of available treatments have found a lack of consistent evidence, and few studies of high quality. Since 2016, no systematic review has been conducted and an up-to date review is requested. In a recent James Lind Alliance collaboration, it was clear that research on effective treatments is a high priority for both patients and clinicians.Material and methodsSearches without time limits were performed in the AMED, CINAHL, Cochrane Library, EMBASE, Medline, PsycINFO, and Scopus databases until June 26, 2023. Studies published before October 1, 2014 were identified from the review by O'Donnell et al., 2016. Selection criteria were randomized clinical trials and non-randomized studies of interventions comparing treatment of hyperemesis gravidarum with another treatment or placebo. Outcome variables included were: degree of nausea; vomiting; inability to tolerate oral fluids or food; hospital treatment; health-related quality of life, small-for-gestational-age infant; and preterm birth. Abstracts and full texts were screened, and risk of bias of the studies was assessed independently by two authors. Synthesis without meta-analysis was performed, and certainty of evidence was assessed using the GRADE approach. PROSPERO (CRD42022303150).ResultsTwenty treatments were included in 25 studies with low or moderate risk of bias. The certainty of evidence was very low for all treatments except for acupressure in addition to standard care, which showed a possible moderate decrease in nausea and vomiting, with low certainty of evidence.ConclusionsSeveral scientific knowledge gaps were identified. Studies on treatments for hyperemesis gravidarum are few, and the certainty of evidence for different treatments is either low or very low. To establish more robust evidence, it is essential to use validated scoring systems, the recently established diagnostic criteria, clear descriptions and measurements of core outcomes and to perform larger studies. The certainty of evidence according to GRADE (The Grading of Recommendations Assessment, Development and Evaluation) was very low for all treatments of hyperemesis gravidarum except for acupressure in addition to standard care, which showed a possible moderate decrease in nausea and vomiting, with low certainty of evidence.image
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- hyperemesis gravidarum
- intervention
- nausea
- PUQE
- quality of life
- systematic review
- treatment
- vomiting
- placebo-controlled trial
- double-blind
- inpatient management
- early-pregnancy
- nausea
- women
- metoclopramide
- ondansetron
- acupressure
- corticosteroids
- Obstetrics & Gynecology
- hyperemesis gravidarum
Publication and Content Type
- ref (subject category)
- art (subject category)
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