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Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP

Vianello, Eleonora (author)
Persson, Josefine, 1980 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Andersson, Björn, 1977 (author)
Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics
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van Veen, Suzanne (author)
Dias, Thomaz Lüscher (author)
Santoro, Francesco (author)
Östensson, Malin, 1984 (author)
Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics
Obudulu, Ogonna, 1976 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Agbajogu, Christopher, 1993 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Torkzadeh, Sara, 1987 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Agnandji, Selidji Todagbe (author)
Ahmed, Rafi (author)
Anderson, Jenna (author)
Auderset, Floriane (author)
Bejon, Philip (author)
Borgianni, Luisa (author)
Brosnahan, Jessica (author)
Ciabattini, Annalisa (author)
Engler, Olivier (author)
Haks, Marielle C. (author)
Harandi, Ali M, 1968 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Heppner, Donald Gray (author)
Gerlini, Alice (author)
Huttner, Angela (author)
Kremsner, Peter G. (author)
Medaglini, Donata (author)
Monath, Thomas (author)
Ndungu, Francis (author)
Njuguna, Patricia (author)
Ottenhoff, Tom H.M. (author)
Pejoski, David (author)
Page, Mark (author)
Pozzi, Gianni (author)
Siegrist, Claire Anne (author)
Dubey, Sheri (author)
Eichberg, Micheal J. (author)
Gonzalez-Dias, Patrícia (author)
Essone, Paulin Ndong (author)
Kabwende, Lumeka (author)
Kremsner, Peter Gottfried (author)
Nakaya, Helder (author)
Nakka, Sravya S. (author)
Haks, Mariëlle C. (author)
Rothenberger, Sylvia (author)
Nakaya, Helder I. (author)
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 (creator_code:org_t)
2023
2023
English.
In: iScience. - 2589-0042. ; 26:12
Related links:
https://gup.ub.gu.se...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus Disease (EVD). In a study of forty-eight healthy adult volunteers who received either the rVSVΔG-ZEBOV-GP vaccine or placebo, we profiled intracellular microRNAs (miRNAs) from whole blood cells (WB) and circulating miRNAs from serum-derived extracellular vesicles (EV) at baseline and longitudinally following vaccination. Further, we identified early miRNA signatures associated with ZEBOV-specific IgG antibody responses at baseline and up to one year post-vaccination, and pinpointed target mRNA transcripts and pathways correlated to miRNAs whose expression was altered after vaccination by using systems biology approaches. Several miRNAs were differentially expressed (DE) and miRNA signatures predicted high or low IgG ZEBOV-specific antibody levels with high classification performance. The top miRNA discriminators were WB-miR-6810, EV-miR-7151-3p, and EV-miR-4426. An eight-miRNA antibody predictive signature was associated with immune-related target mRNAs and pathways. These findings provide valuable insights into early blood biomarkers associated with rVSVΔG-ZEBOV-GP vaccine-induced IgG antibody responses.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

Health sciences
Immunology
Molecular biology
Virology

Publication and Content Type

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art (subject category)

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