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Cluster Analysis of...
Cluster Analysis of Finnish Population-Based Adult-Onset Asthma Patients
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Ilmarinen, P. (author)
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Julkunen-Iivari, A. (author)
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Odont, L. (author)
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Lundberg, M. (author)
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Luukkainen, A. (author)
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Nuutinen, M. (author)
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Karjalainen, J. (author)
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Huhtala, H. (author)
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Pekkanen, J. (author)
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- Kankaanranta, Hannu, 1967 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Toppila-Salmi, S. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of Allergy and Clinical Immunology-in Practice. - 2213-2198. ; 11:10, s. 3086-3096
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Abstract
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- BACKGROUND: Phenotypes of adult asthma have been identified in previous studies but rarely in population-based settings.OBJECTIVE: To identify clusters of adult-onset asthma in a Finnish population-based study on subjects born before 1967.METHODS: We used population-based data from 1350 asthmatics with adult-onset asthma (Adult Asthma in Finland) from Finnish national registers. Twenty-eight covariates were selected based on literature. The number of covariates was reduced by using factor analysis before cluster analysis.RESULTS: Five clusters (CLU1-CLU5) were identified, 3 clusters with late-onset adult asthma (onset >= 40 years) and 2 clusters with onset at earlier adulthood (<40 years). Subjects in CLU1 (n = 666) had late-onset asthma and were nonobese, symptomatic, and predominantly female with few respiratory infections during childhood. CLU2 (n = 36) consisted of subjects who had earlier-onset asthma, were predominantly female, obese with allergic asthma, and had recurrent respiratory infections. Subjects in CLU3 (n = 75) were nonobese, older, and predominantly men with late-onset asthma, smoking history, comorbidities, severe asthma, least allergic diseases, low education, many siblings, and childhood in rural areas. CLU4 (n = 218) was a late-onset cluster consisting of obese females with comorbidities, asthma symptoms, and low education level. Subjects in CLU5 (n [ 260) had earlier onset asthma, were nonobese, and predominantly allergic females.CONCLUSIONS: Our population-based adult-onset asthma clusters take into account several critical factors such as obesity and smoking, and identified clusters that partially overlap with clusters identified in clinical settings. Results give us a more profound understanding of adult-onset asthma phenotypes and support personalized management. (c) 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/). (J Allergy Clin Immunol Pract 2023;11:3086-96)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Adult-onset asthma
- Factor analysis
- Cluster analysis
- Population-based
- research
- respiratory-infections
- prevalence
- phenotypes
- diagnosis
- disease
- age
- endotypes
- siblings
- allergy
- gender
- Allergy
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ilmarinen, P.
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Julkunen-Iivari, ...
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Odont, L.
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Lundberg, M.
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Luukkainen, A.
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Nuutinen, M.
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show more...
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Karjalainen, J.
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Huhtala, H.
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Pekkanen, J.
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Kankaanranta, Ha ...
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Toppila-Salmi, S ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Journal of Aller ...
- By the university
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University of Gothenburg