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  • Safari, Cecilia,1989Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)

Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

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  • LIBRIS-ID:oai:gup.ub.gu.se/332517
  • https://gup.ub.gu.se/publication/332517URI
  • https://doi.org/10.1126/sciadv.adh4179DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cytochrome c oxidase (CcO) is part of the respiratory chain and contributes to the electrochemical membrane gradient in mitochondria as well as in many bacteria, as it uses the energy released in the reduction of oxygen to pump protons across an energy-transducing biological membrane. Here, we use time-resolved serial femtosecond crystallography to study the structural response of the active site upon flash photolysis of carbon monoxide (CO) from the reduced heme a3 of ba3-type CcO. In contrast with the aa3-type enzyme, our data show how CO is stabilized on CuB through interactions with a transiently ordered water molecule. These results offer a structural explanation for the extended lifetime of the CuB-CO complex in ba3-type CcO and, by extension, the extremely high oxygen affinity of the enzyme.

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  • Ghosh, Swagatha,1987Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xghosw (author)
  • Andersson, Rebecka,1988Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xarebe (author)
  • Johannesson, Jonatan,1993Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xjohag (author)
  • Båth, Petra,1988Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xbatpe (author)
  • Uwangue, OwensGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xuwaow (author)
  • Dahl, Peter,1965Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xdapet (author)
  • Zoric, Doris,1994Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xzordo (author)
  • Sandelin, Emil,1994Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xsemik (author)
  • Vallejos, Adams,1987Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)Xvalad (author)
  • Nango, Eriko (author)
  • Tanaka, Rie (author)
  • Bosman, Robert,1991Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xbosro (author)
  • Börjesson, PerGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)
  • Dunevall, Elin,1986Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xjelix (author)
  • Hammarin, Greger,1981Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xhamgr (author)
  • Ortolani, Giorgia,1985Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xortgi (author)
  • Panman, Matthijs R,1983Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xpanmb (author)
  • Tanaka, Tomoyuki (author)
  • Yamashita, Ayumi (author)
  • Arima, Toshi (author)
  • Sugahara, Michihiro (author)
  • Suzuki, Mamoru (author)
  • Masuda, Tetsuya (author)
  • Takeda, Hanae (author)
  • Yamagiwa, Raika (author)
  • Oda, Kazumasa (author)
  • Fukuda, Masahiro (author)
  • Tosha, Takehiko (author)
  • Naitow, Hisashi (author)
  • Owada, Shigeki (author)
  • Tono, Kensuke (author)
  • Nureki, Osamu (author)
  • Iwata, So (author)
  • Neutze, Richard,1969Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xneuri (author)
  • Brändén, Gisela,1975Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xbragi (author)
  • Göteborgs universitetInstitutionen för kemi och molekylärbiologi (creator_code:org_t)

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  • In:Science advances9:492375-2548

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