SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/332684"
 

Search: onr:"swepub:oai:gup.ub.gu.se/332684" > Excessive copper im...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Schwarz, Maria (author)

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/332684
  • https://gup.ub.gu.se/publication/332684URI
  • https://doi.org/10.1038/s41467-023-39245-3DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated, as increasing copper and decreasing selenium levels are observed in blood during aging and inflammation. Here we show that copper treatment increased intracellular selenium and SELENOP in hepatocytes and decreased extracellular SELENOP levels. Hepatic accumulation of copper is a characteristic of Wilson's disease. Accordingly, SELENOP levels were low in serum of Wilson's disease patients and Wilson's rats. Mechanistically, drugs targeting protein transport in the Golgi complex mimicked some of the effects observed, indicating a disrupting effect of excessive copper on intracellular SELENOP transport resulting in its accumulation in the late Golgi. Our data suggest that hepatic copper levels determine SELENOP release from the liver and may affect selenium transport to peripheral organs such as the brain.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Meyer, Caroline E (author)
  • Löser, Alina (author)
  • Lossow, Kristina (author)
  • Hackler, Julian (author)
  • Ott, Christiane (author)
  • Jäger, Susanne (author)
  • Mohr, Isabelle (author)
  • Eklund, Ella AGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Sahlgrenska Centrum för Cancerforskning (SCCR),Wallenberg Centre for Molecular and Translational Medicine,Institute of Clinical Sciences, Department of Surgery,Sahlgrenska Center for Cancer Research (SCCR) (author)
  • Patel, Angana A. H.Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberg Centre for Molecular and Translational Medicine,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Clinical Sciences, Department of Surgery,Sahlgrenska Center for Cancer Research (SCCR)(Swepub:gu)xpatea (author)
  • Gul, Nadia,1980Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Sahlgrenska Centrum för Cancerforskning (SCCR),Sahlgrenska Center for Cancer Research (SCCR)(Swepub:gu)xgulna (author)
  • Alvarez, SamanthaGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Sahlgrenska Centrum för Cancerforskning (SCCR),Sahlgrenska Center for Cancer Research (SCCR) (author)
  • Altinonder, Ilayda,1996Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xaltil (author)
  • Wiel, Clotilde,1987Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberg Centre for Molecular and Translational Medicine,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Clinical Sciences, Department of Surgery,Sahlgrenska Center for Cancer Research (SCCR)(Swepub:gu)xwiecl (author)
  • Maares, Maria (author)
  • Haase, Hajo (author)
  • Härtlova, AnettaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xsvian (author)
  • Grune, Tilman (author)
  • Schulze, Matthias B (author)
  • Schwerdtle, Tanja (author)
  • Merle, Uta (author)
  • Zischka, Hans (author)
  • Sayin, Volkan I.,1983Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberg Centre for Molecular and Translational Medicine,Sahlgrenska Center for Cancer Research (SCCR),Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xsayvo (author)
  • Schomburg, Lutz (author)
  • Kipp, Anna P (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi (creator_code:org_t)

Related titles

  • In:Nature communications14:12041-1723

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view