Search: onr:"swepub:oai:gup.ub.gu.se/332779" >
The impact of hybri...
The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying therapies
- Article/chapterEnglish2023
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/332779
-
https://gup.ub.gu.se/publication/332779URI
-
https://doi.org/10.1111/ene.16015DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:153938533URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background and purpose: Hybrid immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develops from a combination of natural infection and vaccine-generated immunity. Multiple sclerosis (MS) disease-modifying therapies (DMTs) have the potential to impact humoral and cellular immunity induced by SARS-CoV-2 vaccination and infection. The aims were to compare antibody and T-cell responses after SARS-CoV-2 mRNA vaccination in persons with MS (pwMS) treated with different DMTs and to assess differences between naively vaccinated pwMS and pwMS with hybrid immunity vaccinated following a previous SARS-CoV-2 infection.Methods: Antibody and T-cell responses were determined in pwMS at baseline and 4 and 12 weeks after the second dose of SARS-CoV-2 vaccination in 143 pwMS with or without previous SARS-CoV-2 infection and 40 healthy controls (HCs). The MS cohort comprised natalizumab (n = 22), dimethylfumarate (n = 23), fingolimod (n = 38), cladribine (n = 30), alemtuzumab (n = 17) and teriflunomide (n = 13) treated pwMS. Immunoglobulin G antibody responses to SARS-CoV-2 antigens were measured using a multiplex bead assay and FluoroSpot was used to assess T-cell responses (interferon gamma and interleukin 13).Results: Humoral and T-cell responses to vaccination were comparable between naively vaccinated HCs and pwMS treated with natalizumab, dimethylfumarate, cladribine, alemtuzumab and teriflunomide, but were suppressed in fingolimod-treated pwMS. Both fingolimod-treated pwMS and HCs vaccinated following a previous SARS-CoV-2 infection had higher antibody levels 4 weeks after vaccination compared to naively vaccinated individuals. Antibody and interferon gamma levels 12 weeks after vaccination were positively correlated with time from last treatment course of cladribine.Conclusion: These findings are of relevance for infection risk mitigation and for vaccination strategies amongst pwMS undergoing DMT.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Thomas, O. G.Karolinska Institutet
(author)
-
Carlin, G.
(author)
-
Khademi, M.Karolinska Institutet
(author)
-
Högelin, K. A.Karolinska Institutet
(author)
-
Malmeström, Clas,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xmalcl
(author)
-
Axelsson, Markus,1975Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xaxmar
(author)
-
Brandt, AnneGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xfranq
(author)
-
Gafvelin, G.
(author)
-
Grönlund, H.Karolinska Institutet
(author)
-
Kockum, I.Karolinska Institutet
(author)
-
Piehl, F.Karolinska Institutet
(author)
-
Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xlycja
(author)
-
Olsson, T.
(author)
-
Hessa, T.
(author)
-
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
Related titles
-
In:European Journal of Neurology30:12, s. 3789-37981351-51011468-1331
Internet link
Find in a library
To the university's database
- By the author/editor
-
Rabenstein, M.
-
Thomas, O. G.
-
Carlin, G.
-
Khademi, M.
-
Högelin, K. A.
-
Malmeström, Clas ...
-
show more...
-
Axelsson, Markus ...
-
Brandt, Anne
-
Gafvelin, G.
-
Grönlund, H.
-
Kockum, I.
-
Piehl, F.
-
Lycke, Jan, 1956
-
Olsson, T.
-
Hessa, T.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
European Journal ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet