Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.

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Fältnamn	Indikatorer	Metadata
000		10385naa a2202305 4500
001		oai:gup.ub.gu.se/332981
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:153440760
024	7	a https://gup.ub.gu.se/publication/3329812 URI
024	7	a https://doi.org/10.1038/s41380-023-02149-12 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1534407602 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Amare, Azmeraw T4 aut
245	1 0	a Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.
264	1	c 2023
520		a Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental healthdisorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P=9.8×10-12, R2=1.9%) and continuous (P=6.4×10-9, R2=2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P=3.9×10-4, R2=0.9%), but not for the continuous outcome (P=0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700	1	a Thalamuthu, Anbupalam4 aut
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Fullerton, Janice M4 aut
700	1	a Ahmed, Muktar4 aut
700	1	a Hartmann, Simon4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Tekola-Ayele, Fasil4 aut
700	1	a Hou, Liping4 aut
700	1	a Hsu, Yi-Hsiang4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Adli, Mazda4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Hasler, Roland4 aut
700	1	a Richard-Lepouriel, Hélène4 aut
700	1	a Perroud, Nader4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Bhattacharjee, Abesh Kumar4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antonio4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Biernacka, Joanna M4 aut
700	1	a Birner, Armin4 aut
700	1	a Marie-Claire, Cynthia4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr M4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Del Zompo, Maria4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Étain, Bruno4 aut
700	1	a Jamain, Stephane4 aut
700	1	a Falkai, Peter4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frisen, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark A4 aut
700	1	a Gard, Sébastien4 aut
700	1	a Garnham, Julie S4 aut
700	1	a Goes, Fernando S4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Fallgatter, Andreas J4 aut
700	1	a Stegmaier, Sophia4 aut
700	1	a Ethofer, Thomas4 aut
700	1	a Biere, Silvia4 aut
700	1	a Petrova, Kristiyana4 aut
700	1	a Schuster, Ceylan4 aut
700	1	a Adorjan, Kristina4 aut
700	1	a Budde, Monika4 aut
700	1	a Heilbronner, Maria4 aut
700	1	a Kalman, Janos L4 aut
700	1	a Kohshour, Mojtaba Oraki4 aut
700	1	a Reich-Erkelenz, Daniela4 aut
700	1	a Schaupp, Sabrina K4 aut
700	1	a Schulte, Eva C4 aut
700	1	a Senner, Fanny4 aut
700	1	a Vogl, Thomas4 aut
700	1	a Anghelescu, Ion-George4 aut
700	1	a Arolt, Volker4 aut
700	1	a Dannlowski, Udo4 aut
700	1	a Dietrich, Detlef4 aut
700	1	a Figge, Christian4 aut
700	1	a Jäger, Markus4 aut
700	1	a Lang, Fabian U4 aut
700	1	a Juckel, Georg4 aut
700	1	a Konrad, Carsten4 aut
700	1	a Reimer, Jens4 aut
700	1	a Schmauß, Max4 aut
700	1	a Schmitt, Andrea4 aut
700	1	a Spitzer, Carsten4 aut
700	1	a von Hagen, Martin4 aut
700	1	a Wiltfang, Jens4 aut
700	1	a Zimmermann, Jörg4 aut
700	1	a Andlauer, Till F M4 aut
700	1	a Fischer, Andre4 aut
700	1	a Bermpohl, Felix4 aut
700	1	a Ritter, Philipp4 aut
700	1	a Matura, Silke4 aut
700	1	a Gryaznova, Anna4 aut
700	1	a Falkenberg, Irina4 aut
700	1	a Yildiz, Cüneyt4 aut
700	1	a Kircher, Tilo4 aut
700	1	a Schmidt, Julia4 aut
700	1	a Koch, Marius4 aut
700	1	a Gade, Kathrin4 aut
700	1	a Trost, Sarah4 aut
700	1	a Haussleiter, Ida S4 aut
700	1	a Lambert, Martin4 aut
700	1	a Rohenkohl, Anja C4 aut
700	1	a Kraft, Vivien4 aut
700	1	a Grof, Paul4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kelsoe, John4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a Ferensztajn-Rochowiak, Ewa4 aut
700	1	a König, Barbara4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan G4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Manchia, Mirkou Karolinska Institutet4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael J4 aut
700	1	a McElroy, Susan4 aut
700	1	a Colom, Francesc4 aut
700	1	a Millischer, Vincentu Karolinska Institutet4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis M4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline M4 aut
700	1	a Nöthen, Markus M4 aut
700	1	a Novák, Tomas4 aut
700	1	a O'Donovan, Claire4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Pisanu, Claudia4 aut
700	1	a Potash, James B4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Rouleau, Guy A4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter R4 aut
700	1	a Schweizer, Barbara W4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shilling, Paul D4 aut
700	1	a Shimoda, Katzutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire M4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Maj, Mario4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Veeh, Julia4 aut
700	1	a Witt, Stephanie H4 aut
700	1	a Wright, Adam4 aut
700	1	a Zandi, Peter P4 aut
700	1	a Mitchell, Philip B4 aut
700	1	a Bauer, Michael4 aut
700	1	a Alda, Martin4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a McMahon, Francis J4 aut
700	1	a Schulze, Thomas G4 aut
700	1	a Clark, Scott R4 aut
700	1	a Baune, Bernhard T4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Molecular psychiatryg 28, s. 5251-5261q 28<5251-5261x 1476-5578
856	4 8	u https://gup.ub.gu.se/publication/332981
856	4 8	u https://doi.org/10.1038/s41380-023-02149-1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:153440760

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By the author/editor: Amare, Azmeraw T; Thalamuthu, Anbu ...; Schubert, Klaus ...; Fullerton, Janic ...; Ahmed, Muktar; Hartmann, Simon; show more...; Papiol, Sergi; Heilbronner, Urs; Degenhardt, Fran ...; Tekola-Ayele, Fa ...; Hou, Liping; Hsu, Yi-Hsiang; Shekhtman, Tatya ...; Adli, Mazda; Akula, Nirmala; Akiyama, Kazufum ...; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Hasler, Roland; Richard-Lepourie ...; Perroud, Nader; Backlund, Lena; Bhattacharjee, A ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Biernacka, Joann ...; Birner, Armin; Marie-Claire, Cy ...; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Cruceanu, Cristi ...; Czerski, Piotr M; Dalkner, Nina; Del Zompo, Maria; DePaulo, J Raymo ...; Étain, Bruno; Jamain, Stephane; Falkai, Peter; Forstner, Andrea ...; Frisen, Louise; Frye, Mark A; Gard, Sébastien; Garnham, Julie S; Goes, Fernando S; Grigoroiu-Serban ...; Fallgatter, Andr ...; Stegmaier, Sophi ...; Ethofer, Thomas; Biere, Silvia; Petrova, Kristiy ...; Schuster, Ceylan; Adorjan, Kristin ...; Budde, Monika; Heilbronner, Mar ...; Kalman, Janos L; Kohshour, Mojtab ...; Reich-Erkelenz, ...; Schaupp, Sabrina ...; Schulte, Eva C; Senner, Fanny; Vogl, Thomas; Anghelescu, Ion- ...; Arolt, Volker; Dannlowski, Udo; Dietrich, Detlef; Figge, Christian; Jäger, Markus; Lang, Fabian U; Juckel, Georg; Konrad, Carsten; Reimer, Jens; Schmauß, Max; Schmitt, Andrea; Spitzer, Carsten; von Hagen, Marti ...; Wiltfang, Jens; Zimmermann, Jörg; Andlauer, Till F ...; Fischer, Andre; Bermpohl, Felix; Ritter, Philipp; Matura, Silke; Gryaznova, Anna; Falkenberg, Irin ...; Yildiz, Cüneyt; Kircher, Tilo; Schmidt, Julia; Koch, Marius; Gade, Kathrin; Trost, Sarah; Haussleiter, Ida ...; Lambert, Martin; Rohenkohl, Anja ...; Kraft, Vivien; Grof, Paul; Hashimoto, Ryota; Hauser, Joanna; Herms, Stefan; Hoffmann, Per; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kuo, Po-Hsiu; Kato, Tadafumi; Kelsoe, John; Kittel-Schneider ...; Ferensztajn-Roch ...; König, Barbara; Kusumi, Ichiro; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan ...; Tortorella, Alfo ...; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan; Colom, Francesc; Millischer, Vinc ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Nöthen, Markus M; Novák, Tomas; O'Donovan, Clair ...; Ozaki, Norio; Pfennig, Andrea; Pisanu, Claudia; Potash, James B; Reif, Andreas; Reininghaus, Eva; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter ...; Schweizer, Barba ...; Severino, Giovan ...; Shilling, Paul D; Shimoda, Katzuta ...; Simhandl, Christ ...; Slaney, Claire M; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Maj, Mario; Turecki, Gustavo; Vieta, Eduard; Veeh, Julia; Witt, Stephanie ...; Wright, Adam; Zandi, Peter P; Mitchell, Philip ...; Bauer, Michael; Alda, Martin; Rietschel, Marce ...; McMahon, Francis ...; Schulze, Thomas ...; Clark, Scott R; Baune, Bernhard ...; show less...

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