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Prognostic performa...
Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.
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Abdelhak, Ahmed (author)
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Barba, Lorenzo (author)
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Romoli, Michele (author)
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Benkert, Pascal (author)
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Conversi, Francesco (author)
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D'Anna, Lucio (author)
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Masvekar, Ruturaj R (author)
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Bielekova, Bibiana (author)
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Prudencio, Mercedes (author)
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Petrucelli, Leonard (author)
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Meschia, James F (author)
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Erben, Young (author)
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Furlan, Roberto (author)
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De Lorenzo, Rebecca (author)
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Mandelli, Alessandra (author)
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Sutter, Raoul (author)
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Hert, Lisa (author)
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Epple, Varenka (author)
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Marastoni, Damiano (author)
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Sellner, Johann (author)
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Steinacker, Petra (author)
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Aamodt, Anne Hege (author)
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Heggelund, Lars (author)
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Dyrhol-Riise, Anne Margarita (author)
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- Virhammar, Johan (author)
- Uppsala universitet,Neurologi
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- Fällmar, David (author)
- Uppsala universitet,Radiologi
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- Rostami, Elham, 1979- (author)
- Uppsala universitet,Neurokirurgi,Förvärvade hjärnskador
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- Kumlien, Eva (author)
- Uppsala universitet,Neurologi
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Tumani, Hayrettin (author)
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Sacco, Simona (author)
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Green, Ari J (author)
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Otto, Markus (author)
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Kuhle, Jens (author)
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Ornello, Raffaele (author)
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Foschi, Matteo (author)
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Abu-Rumeileh, Samir (author)
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(creator_code:org_t)
- Springer, 2023
- 2023
- English.
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In: Journal of neurology. - : Springer. - 1432-1459 .- 0340-5354. ; 270:7, s. 3315-3328
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Abstract
Subject headings
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- To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).We conducted an individual participant data (IPD) meta-analysis after screening on MEDLINE and Scopus to May 23rd2022. We included studies with hospitalized adult COVID-19 patients without major COVID-19-associated central nervous system (CNS) manifestations and with a measurement of blood NfL in the acute phase as well as data regarding at least one clinical outcome including intensive care unit (ICU)admission, need of mechanical ventilation (MV) and death. We derived the age-adjusted measures NfL Z scores and conducted mixed-effects modelling to test associations between NfL Z scores and other variables, encompassing clinical outcomes. Summary receiver operating characteristic curves (SROCs) were used to calculate the area under the curve (AUC) for blood NfL.We identified 382 records, of which 7 studies were included with a total of 669 hospitalized COVID-19 cases (mean age 66.2±15.0years, 68.1% males). Median NfL Z score at admission was elevated compared to the age-corrected reference population (2.37, IQR: 1.13-3.06, referring to 99th percentile in healthy controls). NfL Z scores were significantly associated with disease duration and severity. Higher NfL Z scores were associated with ahigher likelihood of ICU admission, need ofMV, and death. SROCs revealed AUCs of 0.74, 0.80 and 0.71 for mortality, need ofMV and ICU admission, respectively.Blood NfL levels were elevated in the acute phase of COVID-19 patients without major CNS manifestations and associated with clinical severity and poor outcome. The marker might ameliorate the performance of prognostic multivariable algorithms in COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Adult
- Male
- Humans
- Middle Aged
- Aged
- Aged
- 80 and over
- Female
- Prognosis
- COVID-19
- Biomarkers
- Intermediate Filaments
- Central Nervous System
- Neurofilament Proteins
- Biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Abdelhak, Ahmed
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Barba, Lorenzo
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Romoli, Michele
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Benkert, Pascal
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Conversi, France ...
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D'Anna, Lucio
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show more...
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Masvekar, Rutura ...
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Bielekova, Bibia ...
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Prudencio, Merce ...
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Petrucelli, Leon ...
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Meschia, James F
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Erben, Young
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Furlan, Roberto
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De Lorenzo, Rebe ...
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Mandelli, Alessa ...
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Sutter, Raoul
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Hert, Lisa
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Epple, Varenka
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Marastoni, Damia ...
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Sellner, Johann
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Steinacker, Petr ...
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Aamodt, Anne Heg ...
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Heggelund, Lars
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Dyrhol-Riise, An ...
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Virhammar, Johan
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Fällmar, David
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Rostami, Elham, ...
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Kumlien, Eva
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Tumani, Hayretti ...
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Sacco, Simona
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Green, Ari J
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Otto, Markus
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Kuhle, Jens
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Ornello, Raffael ...
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Foschi, Matteo
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Abu-Rumeileh, Sa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of neuro ...
- By the university
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University of Gothenburg
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Karolinska Institutet
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Uppsala University