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Antibody responses ...
Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability
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Huttner, Angela (author)
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Agnandji, Selidji Todagbe (author)
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Engler, Olivier (author)
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Hooper, Jay W. (author)
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Kwilas, Steve (author)
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Ricks, Keersten (author)
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Clements, Tamara L. (author)
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Jonsdottir, Hulda R. (author)
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- Nakka, Sravya Sowdamini (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Rothenberger, Sylvia (author)
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Kremsner, Peter (author)
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Zust, Roland (author)
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Medaglini, Donata (author)
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Ottenhoff, Tom (author)
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- Harandi, Ali M, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Siegrist, Claire-Anne (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: CLINICAL MICROBIOLOGY AND INFECTION. - 1198-743X .- 1469-0691. ; 29:12, s. 1587-1594
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objectives: To report 5-year persistence and avidity of antibodies produced by the live-attenuated recombinant vesicular stomatitis virus (rVSV) expressing the Zaire Ebolavirus (ZEBOV) glycoprotein (GP), known as rVSV-ZEBOV (Ervebo (R)).Methods: Healthy adults vaccinated with 300,000 or 10-50 million plaque-forming units of rVSV-ZEBOV in the WHO-coordinated trials of 2014-2015 were followed for up to 4 (Lambar & eacute;n & eacute;, Gabon) and 5 (Geneva, Switzerland) years. We report seropositivity rates, geometric mean titres (GMTs), and population distribution of ZEBOV-GP ELISA IgG antibodies, neutralizing antibodies (pseudovirus and live-virus neutralization) and antibody avidity; the primary outcome was ZEBOV-GP ELISA IgG GMTs at 4 or 5 years compared with 1 year (Y1) after immunization.Results: Among the 168 eligible vaccinees (Geneva: 97 and Lambar & eacute;n & eacute;: 71) enrolled 1 year post-immunization, 146 (87%) remained enrolled at 4 years (Geneva: n = 88, Lambar & eacute;n & eacute;: n = 58), and 84 (87%, Geneva) at 5 years post-vaccination. ZEBOV-GP ELISA IgG GMTs plateaued, with no declining trend from 1 year through the last time point assessed (1147.8 [95% CI 874.3-1507.0] at Y1 versus 1548.1 [95% CI 1136.6-2108.5] at Y5 in Geneva volunteers receiving >= 10 million plaque-forming units of rVSV-ZEBOV), their avidity matching that of ZEBOV convalescents. Live-virus neutralizing antibodies were detected for shorter periods and in fewer vaccinees (53/95 [56%] at Y1 versus 35/84 [42%] at Y5 in Geneva volunteers, all dose levels).Discussion: Titres at Y1 emerged as a correlate of antibody persistence at Y5. The findings of persistent ZEBOV-GP ELISA IgG titres yet shorter-lasting, lower titres of live-virus neutralizing antibodies suggest the contribution of antibody-mediated protective mechanisms other than neutralization. Long-term clinical efficacy of rVSV-ZEBOV, however, requires further study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Antibody avidity
- Antibody persistence
- Ebola virus disease
- Immunogenicity
- Neutralizing antibodies
- Vaccine
Publication and Content Type
- ref (subject category)
- art (subject category)
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Huttner, Angela
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Agnandji, Selidj ...
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Engler, Olivier
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Hooper, Jay W.
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Kwilas, Steve
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Ricks, Keersten
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show more...
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Clements, Tamara ...
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Jonsdottir, Huld ...
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Nakka, Sravya So ...
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Rothenberger, Sy ...
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Kremsner, Peter
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Zust, Roland
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Medaglini, Donat ...
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Ottenhoff, Tom
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Harandi, Ali M, ...
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Siegrist, Claire ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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CLINICAL MICROBI ...
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University of Gothenburg