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  • Hegen, Harald (author)

Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study

  • Article/chapterEnglish2023

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  • 2023

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  • LIBRIS-ID:oai:gup.ub.gu.se/333553
  • https://gup.ub.gu.se/publication/333553URI
  • https://doi.org/10.3389/fimmu.2023.1327947DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • BackgroundKappa free light chains (kappa-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).ObjectiveTo investigate whether kappa-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).MethodsPatients with PPMS were recruited through 11 MS centres across 7 countries. kappa-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.ResultsA total of 174 patients (mean age of 52 +/- 11 years, 51% males) were included. kappa-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.Conclusion kappa-FLC index shows similar diagnostic sensitivity than OCB in PPMS.

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  • Berek, Klaus (author)
  • Cavalla, Paola (author)
  • Christiansen, Mikael (author)
  • Emersic, Andreja (author)
  • Di Filippo, Massimiliano (author)
  • Gaetani, Lorenzo (author)
  • Hassler, Michaela (author)
  • Leurs, Cyra (author)
  • Milosavljevic, Dejan (author)
  • van Pesch, Vincent (author)
  • Petersen, Thor (author)
  • Presslauer, Stefan (author)
  • Rosenstein, Igal,1984Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xrosig (author)
  • Rot, Uros (author)
  • Schnabl, Christine (author)
  • Teunissen, Charlotte (author)
  • Vecchio, Domizia (author)
  • Vercellino, Marco (author)
  • Deisenhammer, Florian (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap (creator_code:org_t)

Related titles

  • In:FRONTIERS IN IMMUNOLOGY141664-3224

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