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Identifying novel i...
Identifying novel inhibitors targeting Exportin-1 for the potential treatment of COVID-19
- Article/chapterEnglish2024
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LIBRIS-ID:oai:gup.ub.gu.se/334558
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https://gup.ub.gu.se/publication/334558URI
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https://doi.org/10.1007/s00203-023-03761-zDOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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The nuclear export protein 1 (XPO1) mediates the nucleocytoplasmic transport of proteins and ribonucleic acids (RNAs) and plays a prominent role in maintaining cellular homeostasis. XPO1 has emerged as a promising therapeutic approach to interfere with the lifecycle of many viruses. In our earlier study, we proved the inhibition of XPO1 as a therapeutic strategy for managing SARS-COV-2 and its variants. In this study, we have utilized pharmacophore-assisted computational methods to identify prominent XPO1 inhibitors. After several layers of screening, a few molecules were shortlisted for further experimental validation on the in vitro SARS-CoV-2 cell infection model. It was observed that these compounds reduced spike positivity, suggesting inhibition of SARS-COV-2 infection. The outcome of this study could be considered further for developing novel antiviral therapeutic strategies against SARS-CoV-2.
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Mondal, Tanmoy,1981Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xmonta
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Khan, Sajid
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Churqui, Marianela Patzi,1987Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xpatma
(author)
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Nyström, Kristina,1977Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xnystk
(author)
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Thombare, KetanGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xthomk
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Baig, Mohammad Hassan
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Dong, Jae-June
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för laboratoriemedicin
(creator_code:org_t)
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In:ARCHIVES OF MICROBIOLOGY206:20302-89331432-072X
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