Search: onr:"swepub:oai:gup.ub.gu.se/334570" >
Association of regi...
Association of region-specific hippocampal reduction of neurogranin with inflammasome proteins in post mortem brains of Alzheimer's disease
-
Vontell, Regina T. (author)
-
Gober, Ryan (author)
-
Dallmeier, Julian (author)
-
show more...
-
Brzostowicki, Daniel (author)
-
Barreda, Ayled (author)
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Kvartsberg, Hlin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Gultekin, Sakir Humayun (author)
-
de Rivero Vaccari, Juan Pablo (author)
-
Bramlett, Helen M. (author)
-
Dietrich, W. Dalton (author)
-
Keane, Robert W. (author)
-
Davis, David A. (author)
-
Rundek, Tatjana (author)
-
Sun, Xiaoyan (author)
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS. - 2352-8737. ; 10:1
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- INTRODUCTION: Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology.METHODS: We investigated the protein expression, morphological differences of Ng, and correlated Ng to hyperphosphorylated tau in the post mortem brains of 17 AD cases and 17 age- and sex-matched controls. In addition, we correlated the Ng expression with two different epitopes of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).RESULTS: We show a reduction of Ng immunopositive neurons and morphological differences in AD compared to controls. Ng immunostaining was negatively correlated with neurofibrillary tangles, humanized anti-ASC (IC100) positive neurons and anti-ASC positive microglia, in AD.DISCUSSION: The finding of a negative correlation between Ng and ASC speck protein expression in post mortem brains of AD suggests that the activation of inflammasome/ASC speck pathway may play an important role in synaptic degeneration in AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- axon
- inflammasome
- microglia
- neurogranin
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Vontell, Regina ...
-
Gober, Ryan
-
Dallmeier, Julia ...
-
Brzostowicki, Da ...
-
Barreda, Ayled
-
Blennow, Kaj, 19 ...
-
show more...
-
Zetterberg, Henr ...
-
Kvartsberg, Hlin ...
-
Gultekin, Sakir ...
-
de Rivero Vaccar ...
-
Bramlett, Helen ...
-
Dietrich, W. Dal ...
-
Keane, Robert W.
-
Davis, David A.
-
Rundek, Tatjana
-
Sun, Xiaoyan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
ALZHEIMERS & DEM ...
- By the university
-
University of Gothenburg