Search: onr:"swepub:oai:gup.ub.gu.se/334880" >
NfL reliability acr...
NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study
-
Linnemann, Christoph (author)
-
Wilke, Carlo (author)
-
Mengel, David (author)
-
show more...
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Heller, Carolin (author)
-
Kuhle, Jens (author)
-
Bouzigues, Arabella (author)
-
Russell, Lucy L. (author)
-
Foster, Phoebe H. (author)
-
Ferry-Bolder, Eve (author)
-
Van Swieten, John Cornelis (author)
-
Jiskoot, Lize C. (author)
-
Seelaar, Harro (author)
-
Moreno, Fermin (author)
-
Borroni, Barbara (author)
-
Sanchez-Valle, Raquel (author)
-
Galimberti, Daniela (author)
-
Laforce Jr, Robert (author)
-
- Graff, Caroline (author)
- Karolinska Institutet
-
Masellis, Mario (author)
-
Tartaglia, Maria Carmela (author)
-
Rowe, James Benedict (author)
-
Finger, Elizabeth (author)
-
Vandenberghe, Rik (author)
-
de Mendonca, Alexandre (author)
-
Butler, Chris R. (author)
-
Gerhard, Alexander (author)
-
Ducharme, Simon (author)
-
Ber, Isabelle L. E. (author)
-
Tiraboschi, Pietro (author)
-
Santana, Isabel (author)
-
Pasquier, Florence (author)
-
Levin, Johannes (author)
-
Otto, Markus (author)
-
Sorbi, Sandro (author)
-
Rohrer, Jonathan Daniel (author)
-
Synofzik, Matthis (author)
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. - 0022-3050 .- 1468-330X.
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BackgroundBlood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to facilitate the use of NfL in gFTD multicentre trials by testing its (1) reliability across labs; (2) reliability to stratify gFTD disease stages; (3) comparability between blood matrices and (4) stability across recruiting sites.MethodsComparative analysis of blood NfL levels in a large gFTD cohort (GENFI) for (1)-(4), with n=344 samples (n=148 presymptomatic, n=11 converter, n=46 symptomatic subjects, with mutations in C9orf72, GRN or MAPT; and n=139 within-family controls), each measured in three different international labs by Simoa HD-1 analyzer.ResultsNfL revealed an excellent consistency (intraclass correlation coefficient (ICC) 0.964) and high reliability across the three labs (maximal bias (pg/mL) in Bland-Altman analysis: 1.12 +/- 1.20). High concordance of NfL across laboratories was moreover reflected by high areas under the curve for discriminating conversion stage against the (non-converting) presymptomatic stage across all three labs. Serum and plasma NfL were largely comparable (ICC 0.967). The robustness of NfL across 13 recruiting sites was demonstrated by a linear mixed effect model.ConclusionsOur results underline the suitability of blood NfL in gFTD multicentre trials, including cross-lab reliable stratification of the highly trial-relevant conversion stage, matrix comparability and cross-site robustness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- COGNITION
- FRONTOTEMPORAL DEMENTIA
- NEUROPSYCHIATRY
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Linnemann, Chris ...
-
Wilke, Carlo
-
Mengel, David
-
Zetterberg, Henr ...
-
Heller, Carolin
-
Kuhle, Jens
-
show more...
-
Bouzigues, Arabe ...
-
Russell, Lucy L.
-
Foster, Phoebe H ...
-
Ferry-Bolder, Ev ...
-
Van Swieten, Joh ...
-
Jiskoot, Lize C.
-
Seelaar, Harro
-
Moreno, Fermin
-
Borroni, Barbara
-
Sanchez-Valle, R ...
-
Galimberti, Dani ...
-
Laforce Jr, Robe ...
-
Graff, Caroline
-
Masellis, Mario
-
Tartaglia, Maria ...
-
Rowe, James Bene ...
-
Finger, Elizabet ...
-
Vandenberghe, Ri ...
-
de Mendonca, Ale ...
-
Butler, Chris R.
-
Gerhard, Alexand ...
-
Ducharme, Simon
-
Ber, Isabelle L. ...
-
Tiraboschi, Piet ...
-
Santana, Isabel
-
Pasquier, Floren ...
-
Levin, Johannes
-
Otto, Markus
-
Sorbi, Sandro
-
Rohrer, Jonathan ...
-
Synofzik, Matthi ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
JOURNAL OF NEURO ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet