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The functional significance of mitochondrial respiratory chain supercomplexes

Kohler, Andreas, Dr. rer. nat. 1988- (author)
Stockholms universitet,Institutionen för biokemi och biofysik,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden; Institute of Molecular Biosciences University of Graz, Graz, Austria
Barrientos, Antoni (author)
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA
Fontanesi, Flavia (author)
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA
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Ott, Martin, 1974 (author)
Stockholms universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Institutionen för biokemi och biofysik,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden
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 (creator_code:org_t)
EMBO Press, 2023
2023
English.
In: EMBO REPORTS. - : EMBO Press. - 1469-221X .- 1469-3178. ; 24:11
  • Research review (peer-reviewed)
Abstract Subject headings
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  • The mitochondrial respiratory chain (MRC) is a key energy transducer in eukaryotic cells. Four respiratory chain complexes cooperate in the transfer of electrons derived from various metabolic pathways to molecular oxygen, thereby establishing an electrochemical gradient over the inner mitochondrial membrane that powers ATP synthesis. This electron transport relies on mobile electron carries that functionally connect the complexes. While the individual complexes can operate independently, they are in situ organized into large assemblies termed respiratory supercomplexes. Recent structural and functional studies have provided some answers to the question of whether the supercomplex organization confers an advantage for cellular energy conversion. However, the jury is still out, regarding the universality of these claims. In this review, we discuss the current knowledge on the functional significance of MRC supercomplexes, highlight experimental limitations, and suggest potential new strategies to overcome these obstacles. Mitochondrial respiratory chain complexes can associate into supramolecular structures termed respiratory supercomplexes. This review discusses their structure, assembly and potential physiological functions.image

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Annan biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Other Biological Topics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

bioenergetics
electron transfer
Mitochondria
respiratory chain
supercomplexes
bioenergetics

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