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A blood-based multi...
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups
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Jiang, Yuanbing (author)
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Uhm, Hyebin (author)
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Ip, Fanny C. (author)
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Ouyang, Li (author)
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Lo, Ronnie M.N. (author)
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Cheng, Elaine Y.L. (author)
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Cao, Xiaoyun (author)
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Tan, Clara M.C. (author)
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Law, Brian C.H. (author)
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Ortiz-Romero, Paula (author)
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Puig-Pijoan, Albert (author)
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Fernández-Lebrero, Aida (author)
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Contador, José (author)
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Mok, Kin Y. (author)
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Hardy, John (author)
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Kwok, Timothy C.Y. (author)
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Mok, Vincent C.T. (author)
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Suárez-Calvet, Marc (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fu, Amy K.Y. (author)
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Ip, Nancy Y. (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Alzheimer's and Dementia. - 1552-5260 .- 1552-5279.
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- INTRODUCTION: Existing blood-based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies on blood-based biomarkers associated with other biological processes for a comprehensive evaluation of AD status are limited. METHODS: We developed a blood-based, multiplex biomarker assay for AD that measures the levels of 21 proteins involved in multiple biological pathways. We evaluated the assay's performance for classifying AD and indicating AD-related endophenotypes in three independent cohorts from Chinese or European-descent populations. RESULTS: The 21-protein assay accurately classified AD (area under the receiver operating characteristic curve [AUC]=0.9407 to 0.9867) and mild cognitive impairment (MCI; AUC=0.8434 to 0.8945) while also indicating brain amyloid pathology. Moreover, the assay simultaneously evaluated the changes of five biological processes in individuals and revealed the ethnic-specific dysregulations of biological processes upon AD progression. DISCUSSION: This study demonstrated the utility of a blood-based, multi-pathway biomarker assay for early screening and staging of AD, providing insights for patient stratification and precision medicine. HIGHLIGHTS: The authors developed a blood-based biomarker assay for Alzheimer's disease. The 21-protein assay classifies AD/MCI and indicates brain amyloid pathology. The 21-protein assay can simultaneously assess activities of five biological processes. Ethnic-specific dysregulations of biological processes in AD were revealed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid pathology
- blood biomarkers
- disease staging
- early detection
- patient stratification
- precision medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jiang, Yuanbing
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Uhm, Hyebin
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Ip, Fanny C.
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Ouyang, Li
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Lo, Ronnie M.N.
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Cheng, Elaine Y. ...
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show more...
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Cao, Xiaoyun
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Tan, Clara M.C.
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Law, Brian C.H.
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Ortiz-Romero, Pa ...
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Puig-Pijoan, Alb ...
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Fernández-Lebrer ...
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Contador, José
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Mok, Kin Y.
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Hardy, John
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Kwok, Timothy C. ...
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Mok, Vincent C.T ...
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Suárez-Calvet, M ...
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Zetterberg, Henr ...
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Fu, Amy K.Y.
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Ip, Nancy Y.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg