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Long-term health-re...
Long-term health-related quality of life in head and neck cancer survivors: A large multinational study
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Taylor, Katherine J. (author)
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Amdal, Cecilie D. (author)
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Bjordal, Kristin (author)
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Astrup, Guro L. (author)
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Herlofson, Bente B. (author)
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Duprez, Frederic (author)
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Gama, Ricardo R. (author)
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Jacinto, Alexandre (author)
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- Hammerlid, Eva, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Scricciolo, Melissa (author)
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Jansen, Femke (author)
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Verdonck-de Leeuw, Irma M. (author)
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Fanetti, Giuseppe (author)
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Guntinas-Lichius, Orlando (author)
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Inhestern, Johanna (author)
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Dragan, Tatiana (author)
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Fabian, Alexander (author)
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Boehm, Andreas (author)
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Woehner, Ulrike (author)
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Kiyota, Naomi (author)
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Krueger, Maximilian (author)
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Bonomo, Pierluigi (author)
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Pinto, Monica (author)
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Nuyts, Sandra (author)
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Silva, Joaquim Castro (author)
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Stromberger, Carmen (author)
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Specenier, Pol (author)
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Tramacere, Francesco (author)
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Bushnak, Ayman (author)
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Perotti, Pietro (author)
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Plath, Michaela (author)
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Paderno, Alberto (author)
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Stempler, Noa (author)
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Kouri, Maria (author)
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Gregoire, Vincent (author)
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Singer, Susanne (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: INTERNATIONAL JOURNAL OF CANCER. - 0020-7136 .- 1097-0215.
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https://doi.org/10.1...
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Abstract
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- Head and neck cancer (HNC) patients suffer from a range of health-related quality of life (HRQoL) issues, but little is known about their long-term HRQoL. This study explored associations between treatment group and HRQoL at least 5 years' post-diagnosis in HNC survivors. In an international cross-sectional study, HNC survivors completed the European Organization for Research and Treatment of Cancer (EORTC) quality of life core questionnaire (EORTC-QLQ-C30) and its HNC module (EORTC-QLQ-H&N35). Meaningful HRQoL differences were examined between five treatment groups: (a) surgery, (b) radiotherapy, (c) chemo-radiotherapy, (d) radiotherapy +/- chemotherapy and neck dissection and (e) any other surgery (meaning any tumour surgery that is not a neck dissection) and radiotherapy +/- chemotherapy. Twenty-six sites in 11 countries enrolled 1105 survivors. They had a median time since diagnosis of 8 years, a mean age of 66 years and 71% were male. After adjusting for age, sex, tumour site and UICC stage, there was evidence for meaningful differences (10 points or more) in HRQoL between treatment groups in seven domains (Fatigue, Mouth Pain, Swallowing, Senses, Opening Mouth, Dry Mouth and Sticky Saliva). Survivors who had single-modality treatment had better or equal HRQoL in every domain compared to survivors with multimodal treatment, with the largest differences for Dry Mouth and Sticky Saliva. For Global Quality of Life, Physical and Social Functioning, Constipation, Dyspnoea and Financial Difficulties, at least some treatment groups had better outcomes compared to a general population. Our data suggest that multimodal treatment is associated with worse HRQoL in the long-term compared to single modality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cross-sectional
- head and neck cancer
- quality of life
- survivor
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Taylor, Katherin ...
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Amdal, Cecilie D ...
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Bjordal, Kristin
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Astrup, Guro L.
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Herlofson, Bente ...
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Duprez, Frederic
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show more...
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Gama, Ricardo R.
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Jacinto, Alexand ...
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Hammerlid, Eva, ...
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Scricciolo, Meli ...
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Jansen, Femke
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Verdonck-de Leeu ...
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Fanetti, Giusepp ...
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Guntinas-Lichius ...
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Inhestern, Johan ...
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Dragan, Tatiana
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Fabian, Alexande ...
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Boehm, Andreas
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Woehner, Ulrike
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Kiyota, Naomi
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Krueger, Maximil ...
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Bonomo, Pierluig ...
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Pinto, Monica
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Nuyts, Sandra
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Silva, Joaquim C ...
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Stromberger, Car ...
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Specenier, Pol
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Tramacere, Franc ...
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Bushnak, Ayman
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Perotti, Pietro
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Plath, Michaela
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Paderno, Alberto
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Stempler, Noa
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Kouri, Maria
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Gregoire, Vincen ...
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Singer, Susanne
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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INTERNATIONAL JO ...
- By the university
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University of Gothenburg