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Screening for Mild ...
Screening for Mild Cognitive Impairment Using a Machine Learning Classifier and the Remote Speech Biomarker for Cognition: Evidence from Two Clinically Relevant Cohorts
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- Schaefer, Simona (author)
- Karolinska Institutet
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Mallick, Elisa (author)
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Schwed, Louisa (author)
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Koenig, Alexandra (author)
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Zhao, Jian (author)
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Linz, Nicklas (author)
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- Hadarsson-Bodin, Timothy (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Skoog, Johan, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Possemis, Nina (author)
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Ter Huurne, Daphne (author)
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- Zettergren, Anna, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Kern, Silke (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Sacuiu, Simona, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Ramakers, Inez (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Troeger, Johannes (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: JOURNAL OF ALZHEIMERS DISEASE. - 1387-2877 .- 1875-8908. ; 91:3, s. 1165-1171
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https://doi.org/10.3...
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Abstract
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- Background: Modern prodromal Alzheimer's disease (AD) clinical trials might extend outreach to a general population, causing high screen-out rates and thereby increasing study time and costs. Thus, screening tools that cost-effectively detect mild cognitive impairment (MCI) at scale are needed. Objective: Develop a screening algorithm that can differentiate between healthy and MCI participants in different clinically relevant populations. Methods: Two screening algorithms based on the remote ki:e speech biomarker for cognition (ki:e SB-C) were designed on a Dutch memory clinic cohort (N= 121) and a Swedish birth cohort (N= 404). MCI classification was each evaluated on the training cohort as well as on the unrelated validation cohort. Results: The algorithms achieved a performance of AUC similar to 0.73 and AUC similar to 0.77 in the respective training cohorts and AUC similar to 0.81 in the unseen validation cohorts. Conclusion: The results indicate that a ki:e SB-C based algorithm robustly detectsMCIacross different cohorts and languages, which has the potential to make current trials more efficient and improve future primary health care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- biomarker
- clinical trial
- machine learning
- mild cognitive impairment
- screening
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schaefer, Simona
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Mallick, Elisa
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Schwed, Louisa
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Koenig, Alexandr ...
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Zhao, Jian
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Linz, Nicklas
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show more...
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Hadarsson-Bodin, ...
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Skoog, Johan, 19 ...
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Possemis, Nina
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Ter Huurne, Daph ...
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Zettergren, Anna ...
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Kern, Silke
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Sacuiu, Simona, ...
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Ramakers, Inez
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Skoog, Ingmar, 1 ...
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Troeger, Johanne ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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JOURNAL OF ALZHE ...
- By the university
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University of Gothenburg
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Karolinska Institutet