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Protein supplementa...
Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes
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Attaye, Ilias (author)
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Lassen, Pierre Bel (author)
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Adriouch, Solia (author)
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Steinbach, Emilie (author)
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Patino-Navarrete, Rafael (author)
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Davids, Mark (author)
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Alili, Rohia (author)
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Jacques, Flavien (author)
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Benzeguir, Sara (author)
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Belda, Eugeni (author)
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Nemet, Ina (author)
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Anderson, James T. (author)
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Alexandre-Heymann, Laure (author)
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Greyling, Arno (author)
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Larger, Etienne (author)
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Hazen, Stanley L. (author)
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van Oppenraaij, Sophie L. (author)
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- Tremaroli, Valentina, 1978 (author)
- Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Beck, Katharina, 1989 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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- Bergh, Per-Olof (author)
- Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Bakhed, Fredrik (author)
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ten Brincke, Suzan P. M. (author)
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Herrema, Hilde (author)
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Groen, Albert K. (author)
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Pinto-Sietsma, Sara-Joan (author)
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Clement, Karine (author)
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Nieuwdorp, Max (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: ISCIENCE. - 2589-0042. ; 26:8
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https://doi.org/10.1...
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Abstract
Subject headings
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- High-protein diets are promoted for individuals with type 2 diabetes (T2D). How-ever, effects of dietary protein interventions on (gut-derived) metabolites in T2D remains understudied. We therefore performed a multi-center, randomized -controlled, isocaloric protein intervention with 151 participants following either 12-week high-protein (HP; 30Energy %, N = 78) vs. low-protein (LP; 10 Energy%, N = 73) diet. Primary objectives were dietary effects on glycemic control which were determined via glycemic excursions, continuous glucose monitors and HbA1c. Secondary objectives were impact of diet on gut microbiota composition and-derived metabolites which were determined by shotgun-metagenomics and mass spectrometry. Analyses were performed using delta changes adjusting for center, baseline, and kidney function when appropriate. This study found that a short-term 12-week isocaloric protein modulation does not affect glycemic parameters or weight in metformin-treated T2D. However, the HP diet slightly worsened kidney function, increased alpha-diversity, and production of potentially harmful microbiota-dependent metabolites, which may affect host metabolism upon prolonged exposure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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ISCIENCE
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- By the author/editor
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Attaye, Ilias
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Lassen, Pierre B ...
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Adriouch, Solia
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Steinbach, Emili ...
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Patino-Navarrete ...
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Davids, Mark
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show more...
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Alili, Rohia
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Jacques, Flavien
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Benzeguir, Sara
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Belda, Eugeni
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Nemet, Ina
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Anderson, James ...
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Alexandre-Heyman ...
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Greyling, Arno
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Larger, Etienne
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Hazen, Stanley L ...
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van Oppenraaij, ...
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Tremaroli, Valen ...
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Beck, Katharina, ...
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Bergh, Per-Olof
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Bakhed, Fredrik
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ten Brincke, Suz ...
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Herrema, Hilde
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Groen, Albert K.
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Pinto-Sietsma, S ...
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Clement, Karine
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Nieuwdorp, Max
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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ISCIENCE
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University of Gothenburg