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Risk of major adver...
Risk of major adverse liver outcomes among first-degree relatives of individuals with MASLD
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- Yang, Wen (author)
- Karolinska Inst, Sweden
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- Ebrahimi, Fahim (author)
- Karolinska Institutet
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden
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- Holmer, Magnus (author)
- Karolinska Institutet
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- Vessby, Johan (author)
- Uppsala Univ, Sweden
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- Ekstedt, Mattias (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Mag- tarmmedicinska kliniken
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- Ludvigsson, Jonas F. (author)
- Karolinska Institutet
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- Shang, Ying (author)
- Karolinska Institutet
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- Hagstrom, Hannes (author)
- Karolinska Institutet
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(creator_code:org_t)
- WILEY, 2024
- 2024
- English.
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In: LIVER INTERNATIONAL. - : WILEY. - 1478-3223 .- 1478-3231.
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https://doi.org/10.1...
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Abstract
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- Background & AimsPrevious studies have suggested an increased risk of major adverse liver outcomes (MALO) in relatives of patients with metabolic dysfunction-associated steatotic liver disease (MASLD). However, granular and longitudinal evidence is lacking on the future risk of MALO among family members of individuals with MASLD.MethodsWe identified 3526 first-degree relatives (FDRs) and 11 079 general population comparators to 1328 patients with MASLD diagnosed between 1974 and 2021, with detailed clinical data, including liver histology in 71% of patients. MALO was defined through diagnostic coding for cirrhosis or its complications. Cox regression models were used to estimate adjusted hazard ratios (aHRs) for MALO among FDRs compared to general population comparators. Cumulative incidence accounting for competing risks was calculated.ResultsDuring a median follow-up of 13.4 years, there were 65 (2%, 1.12/1000 person-years) and 225 (2%, 1.26/1000 person-years) MALO events in FDRs and general population comparators respectively. After adjusting for demographic factors and comorbidities, FDRs were at no increased risk of MALO (aHR = 0.99, 95% CI: 0.74-1.33). Increased relative rates of MALOs were, however, observed in some subgroups, including parents, although absolute risk estimates were low and comparable to the general population.ConclusionsFDRs of patients with MASLD did not have a higher rate of incident MALO than the general population. Since the absolute risk of MALO in relatives of patients with MASLD was low, these results do not support systematic screening of MASLD-related fibrosis in relatives of patients with MASLD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- first-degree relative
- genetic risk
- major adverse liver outcomes
- metabolic dysfunction-associated steatotic liver disease
- first-degree relative; genetic risk; major adverse liver outcomes; metabolic dysfunction-associated steatotic liver disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Yang, Wen
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Ebrahimi, Fahim
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Romeo, Stefano, ...
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Holmer, Magnus
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Vessby, Johan
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Ekstedt, Mattias
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show more...
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Ludvigsson, Jona ...
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Shang, Ying
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Hagstrom, Hannes
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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LIVER INTERNATIO ...
- By the university
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University of Gothenburg
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Linköping University
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Karolinska Institutet