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A vision for safer ...
A vision for safer food contact materials: Public health concerns as drivers for improved testing
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Muncke, Jane (author)
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Andersson, Anna-Maria (author)
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- Backhaus, Thomas, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
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Belcher, Scott M. (author)
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Boucher, Justin M. (author)
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- Carney Almroth, Bethanie, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
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Collins, Terrence J. (author)
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Geueke, Birgit (author)
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Groh, Ksenia J. (author)
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Heindel, Jerrold J. (author)
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von Hippel, Frank A. (author)
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Legler, Juliette (author)
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Maffini, Maricel V. (author)
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V. Martin, Olwenn (author)
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Myers, John Peterson (author)
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Nadal, Angel (author)
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Nerin, Cristina (author)
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Soto, Ana M. (author)
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Trasande, Leonardo (author)
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Vandenberg, Laura N. (author)
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Wagner, Martin (author)
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Zimmermann, Lisa (author)
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Zoeller, R. Thomas (author)
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Scheringer, Martin (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: ENVIRONMENT INTERNATIONAL. - 0160-4120 .- 1873-6750. ; 180
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Food contact materials (FCMs) and food contact articles are ubiquitous in today's globalized food system. Chemicals migrate from FCMs into foodstuffs, so called food contact chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health from hazardous FCCs because only individual substances used to make FCMs are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, FCMs are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. FCMs can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of FCMs may be improved by (1) testing the overall migrate, including (unknown) NIAS, of finished food contact articles, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. Toidentify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact articles should be tested for their impacts on these SCOD. Research should focus on developing robust, relevant, and sensitive in-vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from FCMs.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Food packaging
- Hazard assessment
- Chronic disease
- Chemical safety
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Muncke, Jane
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Andersson, Anna- ...
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Backhaus, Thomas ...
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Belcher, Scott M ...
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Boucher, Justin ...
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Carney Almroth, ...
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show more...
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Collins, Terrenc ...
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Geueke, Birgit
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Groh, Ksenia J.
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Heindel, Jerrold ...
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von Hippel, Fran ...
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Legler, Juliette
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Maffini, Maricel ...
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V. Martin, Olwen ...
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Myers, John Pete ...
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Nadal, Angel
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Nerin, Cristina
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Soto, Ana M.
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Trasande, Leonar ...
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Vandenberg, Laur ...
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Wagner, Martin
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Zimmermann, Lisa
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Zoeller, R. Thom ...
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Scheringer, Mart ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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ENVIRONMENT INTE ...
- By the university
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University of Gothenburg