Search: onr:"swepub:oai:gup.ub.gu.se/335664" >
Outcomes by sex in ...
Outcomes by sex in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial.
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/335664
-
https://gup.ub.gu.se/publication/335664URI
-
https://doi.org/10.4244/EIJ-D-24-00011DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
In the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial, among participants with stable coronary artery disease, the risk of cardiac events was similar between an invasive (INV) strategy of angiography and coronary revascularisation and a conservative (CON) strategy of initial medical therapy alone. Outcomes according to participant sex were not reported.We aimed to analyse the outcomes of ISCHEMIA by participant sex.We evaluated 1) the association between participant sex and the likelihood of undergoing revascularisation for participants randomised to the INV arm; 2) the risk of the ISCHEMIA primary composite outcome (cardiovascular death, any myocardial infarction [MI] or rehospitalisation for unstable angina, heart failure or resuscitated cardiac arrest) by participant sex; and 3) the contribution of the individual primary outcome components to the composite outcome by participant sex.Of 5,179 randomised participants, 1,168 (22.6%) were women. Female sex was independently associated with a lower likelihood of revascularisation when assigned to the INV arm (adjusted odds ratio 0.75, 95% confidence interval [CI]: 0.57-0.99; p=0.04). The INV versus CON effect on the primary composite outcome was similar between sexes (women: hazard ratio [HR] 0.96, 95% CI: 0.70-1.33; men: HR 0.90, 95% CI: 0.76-1.07; pinteraction=0.71). The contribution of the individual components to the composite outcome was similar between sexes except for procedural MI, which was significantly lower in women (9/151 [5.9%]) than men (67/519 [12.9%]; p=0.01).In ISCHEMIA, women assigned to the INV arm were less likely to undergo revascularisation than men. The effect of an INV versus CON strategy was consistent by sex, but women had a significantly lower contribution of procedural MI to the primary outcome.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Alexander, John H
(author)
-
Sandner, Sigrid
(author)
-
Harik, Lamia
(author)
-
Kim, Jessica
(author)
-
Stone, Gregg W
(author)
-
Rahouma, Mohamed
(author)
-
O'Gara, Patrick
(author)
-
Bhatt, Deepak L
(author)
-
Redfors, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xredbj
(author)
-
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Related titles
-
In:EuroIntervention20:9, s. 551-5601774-024X1969-6213
Internet link
Find in a library
To the university's database
- By the author/editor
-
Gaudino, Mario
-
Alexander, John ...
-
Sandner, Sigrid
-
Harik, Lamia
-
Kim, Jessica
-
Stone, Gregg W
-
show more...
-
Rahouma, Mohamed
-
O'Gara, Patrick
-
Bhatt, Deepak L
-
Redfors, Björn
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
EuroIntervention
- By the university
-
University of Gothenburg