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Toward ovarian canc...
Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid
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- Hedlund Lindberg, Julia (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Widgren, Anna (author)
- Uppsala universitet,Analytisk kemi
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- Ivansson, Emma (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi
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- Gustavsson, Inger M. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi
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- Stålberg, Karin (author)
- Uppsala universitet,Reproduktiv hälsa
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- Gyllensten, Ulf B. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi
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- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi
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- Enroth, Stefan, 1976- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Kollegiet för avancerade studier (SCAS),Genomik och neurobiologi
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(creator_code:org_t)
- Cell Press, 2024
- 2024
- English.
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In: iScience. - : Cell Press. - 2589-0042. ; 27:2
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Early detection is key for increased survival in ovarian cancer, but no general screening program exists today due to lack of biomarkers and overall cost versus benefit over traditional clinical methods. Here, we used dried cervico-vaginal fluid (CVF) as sampling matrix coupled with mass spectrometry for detection of protein biomarkers. We find that self-collected CVF on paper cards yields robust results and is suitable for high-throughput proteomics. Artificial intelligence–based methods were used to identify an 11-protein panel that separates cases from controls. In validation data, the panel achieved a sensitivity of 0.97 (95% CI 0.91–1.00) at a specificity of 0.67 (0.40–0.87). Analyses of samples collected prior to development of symptoms indicate that the panel is informative also of future risk of disease. Dried CVF is used in cervical cancer screening, and our results opens the possibility for a screening program also for ovarian cancer, based on self-collected CVF samples.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Body substance sample
- Cancer
- Fluid
- Proteomics
- Women's health
- Body substance sample
Publication and Content Type
- ref (subject category)
- art (subject category)
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