SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/335712"
 

Search: onr:"swepub:oai:gup.ub.gu.se/335712" > Toward ovarian canc...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Hedlund Lindberg, JuliaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab (author)

Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Cell Press,2024

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/335712
  • https://gup.ub.gu.se/publication/335712URI
  • https://doi.org/10.1016/j.isci.2024.109001DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523401URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Early detection is key for increased survival in ovarian cancer, but no general screening program exists today due to lack of biomarkers and overall cost versus benefit over traditional clinical methods. Here, we used dried cervico-vaginal fluid (CVF) as sampling matrix coupled with mass spectrometry for detection of protein biomarkers. We find that self-collected CVF on paper cards yields robust results and is suitable for high-throughput proteomics. Artificial intelligence–based methods were used to identify an 11-protein panel that separates cases from controls. In validation data, the panel achieved a sensitivity of 0.97 (95% CI 0.91–1.00) at a specificity of 0.67 (0.40–0.87). Analyses of samples collected prior to development of symptoms indicate that the panel is informative also of future risk of disease. Dried CVF is used in cervical cancer screening, and our results opens the possibility for a screening program also for ovarian cancer, based on self-collected CVF samples.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Widgren, AnnaUppsala universitet,Analytisk kemi(Swepub:uu)gansc354 (author)
  • Ivansson, EmmaUppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi(Swepub:uu)emfra062 (author)
  • Gustavsson, Inger M.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi(Swepub:uu)ingergus (author)
  • Stålberg, KarinUppsala universitet,Reproduktiv hälsa(Swepub:uu)kariglim (author)
  • Gyllensten, Ulf B.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi(Swepub:uu)ulfgyll (author)
  • Sundfeldt, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsukar (author)
  • Bergquist, JonasUppsala universitet,Analytisk kemi(Swepub:uu)jbe25356 (author)
  • Enroth, Stefan,1976-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Kollegiet för avancerade studier (SCAS),Genomik och neurobiologi(Swepub:uu)stenr451 (author)
  • Uppsala universitetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)

Related titles

  • In:iScience: Cell Press27:22589-0042

Internet link

Find in a library

  • iScience (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view