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Subsequent correlat...
Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease
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Shim, Kyu Hwan (author)
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Kim, Danyeong (author)
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Kang, Min Ju (author)
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Pyun, Jung-Min (author)
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Park, Young Ho (author)
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Youn, Young Chul (author)
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Park, Kyung Won (author)
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Suk, Kyoungho (author)
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Lee, Ho-Won (author)
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- Fernandes Gomes, Bárbara (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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An, Seong Soo A. (author)
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Kim, Sangyun (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ALZHEIMERS & DEMENTIA. - 1552-5260 .- 1552-5279.
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https://doi.org/10.1...
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Abstract
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- INTRODUCTIONAlzheimer's disease (AD) involves the complement cascade, with complement component 3 (C3) playing a key role. However, the relationship between C3 and amyloid beta (A beta) in blood is limited.METHODSPlasma C3 and A beta oligomerization tendency (A beta Ot) were measured in 35 AD patients and 62 healthy controls. Correlations with cerebrospinal fluid (CSF) biomarkers, cognitive impairment, and amyloid positron emission tomography (PET) were analyzed. Differences between biomarkers were compared in groups classified by concordances of biomarkers.RESULTSPlasma C3 and A beta Ot were elevated in AD patients and in CSF or amyloid PET-positive groups. Weak positive correlation was found between C3 and A beta Ot, while both had strong negative correlations with CSF A beta 42 and cognitive performance. Abnormalities were observed for A beta Ot and CSF A beta 42 followed by C3 changes.DISCUSSIONIncreased plasma C3 in AD are associated with amyloid pathology, possibly reflecting a defense response for A beta clearance. Further studies on A beta-binding proteins will enhance understanding of A beta mechanisms in blood.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid beta
- biomarker
- complement component 3
- oligomer
- plasma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Shim, Kyu Hwan
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Kim, Danyeong
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Kang, Min Ju
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Pyun, Jung-Min
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Park, Young Ho
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Youn, Young Chul
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show more...
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Park, Kyung Won
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Suk, Kyoungho
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Lee, Ho-Won
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Fernandes Gomes, ...
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Zetterberg, Henr ...
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An, Seong Soo A.
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Kim, Sangyun
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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ALZHEIMERS & DEM ...
- By the university
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University of Gothenburg